Table 3

Immunological and virological response to ART among all ART-naïve adolescents and perinatally infected adolescents (9-19 years) compared with that of young adults (20-28 years)

Characteristics

All ART-naïve adolescents

N = 64

ART-naïve young adults

N = 715

P-value†

ART-naïve perinatally-infected adolescents N = 31

P-value†


Baseline CD4 (cells/μL), median (IQR)

139 (62-198)

117 (59-170)

0.15

170 (78-228)

0.026


CD4 (cells/μL), median (IQR) change from baseline


16 weeks

220 (133.5-314)

121 (67-199)

0.0001

188.5 (126-322)

0.0004


32 weeks

195 (136-439)

155 (97-238)

0.0008

256 (172-487)

0.0002


48 weeks

373 (255-518)

187 (118-285)

0.0001

374 (242-631)

0.0002


Virological suppression*, n(%)


16 weeks

36 (97.3)

490 (89.6)

0.13

27 (100.0)

0.077


32 weeks

12 (37.5)

331 (75.1)

< 0.001

7 (28.0)

< 0.001


48 weeks

9 (27.3)

270 (63.1)

< 0.001

6 (24.0)

< 0.001


†The p values were compared with young adults and calculated using Wilcoxon rank-sum test for continuous variables and fishers exact test for binary variables.

*The denominators at 16 weeks for all ART-naïve adolescents, perinatally infected adolescents and young adults were 37, 27 and 547 respectively; at 32 weeks was 32, 25 and 440 respectively and at 48 weeks was 33, 25 and 427 respectively.

Nglazi et al. BMC Infectious Diseases 2012 12:21   doi:10.1186/1471-2334-12-21

Open Data