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Open Access Highly Accessed Research article

Timing of progression from Chlamydia trachomatis infection to pelvic inflammatory disease: a mathematical modelling study

Sereina A Herzog1*, Christian L Althaus1, Janneke CM Heijne1, Pippa Oakeshott2, Sally Kerry4, Phillip Hay3 and Nicola Low1

Author Affiliations

1 Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, CH-3012, Switzerland

2 Division of Population Health Sciences and Education, St George’s, University of London, London, SW17 0RE, UK

3 Department of Genitourinary Medicine, St George’s Hospital, London, SW17 0QT, UK

4 Centre for Primary Care and Public Health, Blizard Institute, Queen Mary University of London, London, E12AB, UK

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BMC Infectious Diseases 2012, 12:187  doi:10.1186/1471-2334-12-187

Published: 11 August 2012

Abstract

Background

Pelvic inflammatory disease (PID) results from the ascending spread of microorganisms from the vagina and endocervix to the upper genital tract. PID can lead to infertility, ectopic pregnancy and chronic pelvic pain. The timing of development of PID after the sexually transmitted bacterial infection Chlamydia trachomatis (chlamydia) might affect the impact of screening interventions, but is currently unknown. This study investigates three hypothetical processes for the timing of progression: at the start, at the end, or throughout the duration of chlamydia infection.

Methods

We develop a compartmental model that describes the trial structure of a published randomised controlled trial (RCT) and allows each of the three processes to be examined using the same model structure. The RCT estimated the effect of a single chlamydia screening test on the cumulative incidence of PID up to one year later. The fraction of chlamydia infected women who progress to PID is obtained for each hypothetical process by the maximum likelihood method using the results of the RCT.

Results

The predicted cumulative incidence of PID cases from all causes after one year depends on the fraction of chlamydia infected women that progresses to PID and on the type of progression. Progression at a constant rate from a chlamydia infection to PID or at the end of the infection was compatible with the findings of the RCT. The corresponding estimated fraction of chlamydia infected women that develops PID is 10% (95% confidence interval 7-13%) in both processes.

Conclusions

The findings of this study suggest that clinical PID can occur throughout the course of a chlamydia infection, which will leave a window of opportunity for screening to prevent PID.

Keywords:
Chlamydia infection; Pelvic inflammatory disease; Mathematical model; Compartmental model; Randomised controlled trials