Figure 4.

Graph showing the diagnostic sensitivity for sputum culture-positive tuberculosis using the Determine TB-LAM assay for lipoarabinomannan (LAM) when used alone or in combination with other diagnostics, including sputum smear microscopy (smear) and Xpert MTB/RIF (Xpert).

Data are stratified by CD4 cell count (cells/μL) and show that the sensitivity of the LAM was substantially greater in the patients with the lowest CD4 cell counts. There was important incremental sensitivity when microscopy and Determine TB-LAM were combined and this was similar to the sensitivity of Xpert in patients with the lowest CD4 cell counts.

Lawn BMC Infectious Diseases 2012 12:103   doi:10.1186/1471-2334-12-103
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