Table 2

Association of HIV and HIV/HCV infection with flow-mediated dilatation, carotid intima-media thickness, and circulating levels of cell adhesion molecules

Variable

Mean difference in log brachial artery FMD, % (95% CI)

P

Mean difference in log carotid IMT, mm

(95% CI)

P

Mean difference in log sICAM-1, ηg/mL (95% CI)

P

Mean difference in log sVCAM-1, ηg/mL (95% CI)

P


HIV/HCV vs. HIV

Unadjusted

0.10 (-0.18-0.38)

0.47

-0.05 (-0.11-0.017)

0.15

0.36 (0.22-0.50)

< 0.001

0.23 (-0.10-0.55)

0.01

Adjusted

0.17 (-0.33-0.68)

0.501

0.05 (-0.05-0.16)

0.273

0.39 (0.14-0.64)

0.0023

0.22 (0.05-0.39)

0.173

HIV/HCV vs. HIV

(patients with VL < 50 c/mL)2

Unadjusted

0.009 (-0.33-0.34)

0.96

-0.08 (-0.16-0.003)

0.06

0.33 (0.14-0.52)

0.001

0.17 (-0.06-0.40)

0.14

Adjusted

0.23 (-0.45-0.90)

0.471

0.014 (-0.13-0.16)

0.243

0.55 (0.19-0.90)

0.0033

0.21 (-0.28-0.69)

0.253


1Adjusted for baseline brachial artery diameter, age, sex, C CDC category, intravenous drug use, men who have sex with men, current protease inhibitor use, lipid-lowering therapy, hypertension, diabetes, smoking, lipodystrophy, systolic blood pressure, fasting total cholesterol and LDL-cholesterol, APRI and FIB-4.

2N = 134

3Adjusted for sex, C CDC category, intravenous drug use, men who have sex with men, current protease inhibitor use, lipid-lowering therapy, smoking, systolic blood pressure, fasting total cholesterol and LDL-cholesterol, APRI and FIB-4.

FMD, flow-mediated dilatation; IMT, intima-media thickness; HCV, hepatitis C virus; CI, confidence interval

Masiá et al. BMC Infectious Diseases 2011 11:265   doi:10.1186/1471-2334-11-265

Open Data