Table 2

Characteristics of the hinges in the trends of CD4+ T-cell counts (two-phase linear regression model)

NNRTI group N = 436/627 (69.4%)

NRTI group N = 145/217 (66.8%)


Time of the hinge relative to the switch (categories)


Before the switch

≤ 180 days from the switch

>180 days from the switch

Before the switch

≤ 180 days from the switch

>180 days from the switch

N = 325/436 (74.5%)

N = 31/436 (7.1%)

N = 80/436 (18.3%)

N = 118/145 (81.4%)

N = 9/145 (6.2%)

N = 18/145 (12.4%)


Increasing CD4+ trend after the hinge relative to the pre-switch trend (categories)


N = 210/325 (64.6%)

N = 7/31 (22.6%)

N = 18/80 (18.7%)

N = 68/145 (46.9%)

N = 3/9 (33.3%)

N = 1/18 (5.5%)


Estimates of the increasing trend (median CD4+/mm3/day, IQR or min-max*/individual$ values where indicated)


1.0003

1.0003

1.0005

1.0003

*min-max:

1.0002 to 1.0005

1.0002 to 1.0082

1.0001 to 1.0015

1.0002 to 1.0004

1.0001 to 1.00025

$1.0001


Stationary CD4+ trend after the hinge relative to the pre-switch trend (categories)


N = 68/325 (20.9%)

N = 8/31 (25.8%)

N = 20/80 (25%)

N = 32/145 (22.1%)

N = 3/9 (33.3%)

N = 5/18 (27.8%)


Decreasing CD4+ trend after the hinge relative to the pre-switch trend (categories)


N = 47/325 (14.5%)

N = 16/31 (51.6%)

N = 45/80 (56.2%)

N = 18/145 (12.4%)

N = 3/9 (33.3%)

N = 12/18 (66.7%)


Estimates of the decreasing trend (median CD4+/mm3/day, IQR or min-max* values where indicated)

-1.0002

-0.99981

-1.0007

-1.0003

*min-max:

-1.0004

-1.0001 to -1.0004

-0.99959 to -0.999945

-1.0029 to 1.0003

-1.0005 to -1.0002

-0.99585 to -0.99988

-1.0015 to -1.0003


Torti et al. BMC Infectious Diseases 2011 11:23   doi:10.1186/1471-2334-11-23

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