Hepatic and extra-hepatic sequelae, and prevalence of viral hepatitis C infection estimated from routine data in at-risk groups
1 Department of Epidemiology, Regional Health System - Lazio Region, Via S. Costanza 53, 00198, Rome, Italy
2 Public Health Agency, Lazio Region, Italy
3 Institute of Microbiology, Medicine Faculty, Catholic University, Rome, Italy
4 Microbiology and Virology Laboratory, S.Filippo Hospital Agency, Rome, Italy
5 Microbiology and Virology Laboratory, S.Giovanni Hospital Agency, Rome, Italy
BMC Infectious Diseases 2010, 10:97 doi:10.1186/1471-2334-10-97Published: 19 April 2010
Additional file 1:
Definitions of at-risk group, data sources and HCV sequelae. This file is organised in three boxes. Box 1 reports the definitions of the groups at risk of HCV infection, on the basis of the information available in the routine data used here. The at-risk groups were: 1) the dialysis patients, 2) the drug users, 3) the patients who underwent digestive system surgery, gynaecological surgery or obstetric, transplants of the heart and/or lungs, of bone marrow or of kidney with the Diagnostic Related Group (DRG) codes or the ICD-9-CM surgery intervention codes used to identify them in the hospital discharge registries; 4) the patients who received a blood transfusion identified with the surgery intervention codes. Box 2 describes the characteristics of the regional dialysis register, the regional drug users surveillance, the hospital discharges registry (HDR) and the information available from these sources that allowed to identify the at-risk groups. Box 3 describes the characteristics of the laboratory surveillance of HCV infection used together with HDR as data sources for HCV infection and the characteristics of the regional Cause Mortality Registry (CMR) used together with the HDR as data sources for the HCV sequelae. The ICD-9-CM codes were reported for both the HCV infection diagnosis and the sequelae.
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Additional file 2:
Prevalence and prevalence ratios of extra-hepatic sequelae in HCV+ and HCV- in at-risk groups. Lazio 1997-2001. This file reports an additional table (table 3) where the prevalence ratios of all the studied extra-hepatic sequelae are reported in detail.
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