Table 3

vivo kinetics of killing of C. elegans infected by E. coli grown in urine samples after consumption of the different proanthocyanidins regimens.

A

LT50 Median (IC95%) in days

P


Regimen

Placebo

18 mg

36 mg

72 mg

Pl vs 18/36

18 vs 36

36 vs 72

6 h vs 24 h

Sp-Fr vs Ja-Hu


Spain


1-6 h

3.5 [3-5]

5 [3-7]

6 [5-8]

ND

<0.001

<0.001

ND

NS except for 72 mg


24 h

3 [3-6]

4.5 [3-6]

5 [3-6]

ND

<0.001

NS

ND

<0.001


France

<0.001


1-6 h

3 [3-5]

5 [4-7]

5.5 [4-7]

ND

<0.001

NS

ND

NS except for 36 mg


24 h

3 [3-5]

3 [2-4]

5 [4-8]

ND

NS

<0.001

ND

<0.001


Japan


1-6 h

4 [3-5]

ND

6.5 [5-9]

7 [5-9]

<0.001

ND

NS

NS


24 h

4 [3-5]

ND

5.5 [4-8]

6 [4-8]

<0.001

ND

NS


<0.001

Hungary


1-6 h

3 [3-5]

ND

5 [4-8]

6 [5-10]

<0.001

ND

NS

NS


24 h

4 [3-5]

ND

5 [4-8]

6 [4-9]

<0.001

ND

NS


Total


1-6 h

3 [3-5]

5 [3-7]

5.5 [4-9]

6.5 [5-10]

<0.001

NS

<0.001

NS

ND


24 h

3.5 [3-5]

4 [2-6]

5 [3-8]

6 [4-9]

<0.001

<0.001

<0.001

ND


OP50

6 [6-7]


B

LT100 Median (IC95%) in days

P


Regimen

Placebo

18 mg

36 mg

72 mg

Pl vs 18/36

18 vs 36

36 vs 72

6 h vs 24 h

Sp-Fr vs Ja-Hu


Spain


1-6 h

8.5 [7-8]

10 [9-10]

11.5 [11-12]

ND

<0.001

<0.001

ND

NS except for 72 mg

<0.001


24 h

7 [6-8]

9 [8-10]

9.5 [9-10]

ND

<0.001

NS

ND

<0.001


France


1-6 h

7 [6-8]

10 [9-11]

11 [10-12]

ND

<0.001

NS

ND

NS except for 36 mg


24 h

7 [6-8]

8 [7-9]

10.5 [10-11]

ND

NS

<0.001

ND

<0.001


Japan

<0.001


1-6 h

8 [7-8]

ND

12.5 [12-13]

13 [12-14]

<0.001

ND

NS

NS


24 h

7.5 [7-8]

ND

11 [10-12]

12 [11-13]

<0.001

ND

NS


Hungary


1-6 h

7 [6-8]

ND

12 [11-13]

12.5 [12-13]

<0.001

ND

NS

NS


24 h

8 [7-8]

ND

11 [10-12]

11.5 [11-12]

<0.001

ND

NS


Total


1-6 h

7 [6-8]

5 [3-7]

5.5 [4-9]

6.5 [5-10]

<0.001

NS

<0.001

NS

ND


24 h

8 [7-8]

4 [2-6]

5 [3-8]

6 [4-9]

<0.001

<0.001

<0.001

ND


OP50

14 [13-15]


(A) Determination of LT50 Median; (B) Determination of LT100 Median.

Howell et al. BMC Infectious Diseases 2010 10:94   doi:10.1186/1471-2334-10-94

Open Data