Table 1

Urinary bacterial Anti-Adhesion Activity (AAA) detected with Mannose-resistant Hemagglutination (MRHA) assay (A) and urinary bacterial adhesion to T24 cells (B) expressed as Adhesion Index (AI) following consumption of increasing doses of cranberry powder standardized for 18, 36 or 72 mg of proanthocyanidins (PAC) vs placebo by participants in the 4 countries.

A

AAA

P


Regimen

Placebo

18 mg PAC

36 mg PAC

72 mg PAC

18 vs 36

36 vs 72

6 h vs 24 h

Sp-Fr vs Ja-Hu


Spain (n = 8)

0 h

0% [0-0]

0% [0-0]

0% [0-0]

ND

1-6 h

0% [0-0]

50% [50-100]

100% [50-100]

ND

0.002

ND

<0.001

<0.001

24 h

0% [0-0]

0% [0-0]

12.5% [0-50]

ND

0.01

ND

<0.001


France (n = 8)

0 h

0% [0-0]

0% [0-0]

0% [0-0]

ND

1-6 h

0% [0-0]

50% [50-100]

75% [50-100]

ND

0.005

ND

<0.001

24 h

0% [0-0]

0% [0-0]

0% [0-0]

ND

NS

ND

<0.001


Japan (n = 8)

<0.001

0 h

12.5% [0-50]

ND

25% [0-50]

25% [0-50]

1-6 h

0% [0-0]

ND

100% [100-100]

100% [100-100]

ND

NS

<0.001

24 h

0% [0-0]

ND

12.5% [0-50]

75% [50-100]

ND

0.001

0.005


Hungary (n = 8)

0 h

0% [0-0]

ND

0% [0-0]

0% [0-0]

1-6 h

0% [0-0]

ND

87.5% [50-100]

100% [100-100]

ND

NS

<0.001

24 h

0% [0-0]

ND

25% [0-50]

25% [0-50]

ND

NS

<0.001


Total (n = 32)

0 h

0.3% [0-0]

0% [0-0]

0.6% [0-50]

12.5% [0-50]

1-6 h

0% [0-0]

50% [50-100]

90.6% [50-100]

100% [100-100]

0.003

NS

<0.001

ND

24 h

0% [0-0]

0% [0-0]

12.5% [0-50]

50% [50-100]

0.01

<0.001

<0.001

ND


B

AI Median [Range]

P


Regimen

Placebo

18 mg PAC

36 mg PAC

72 mg PAC

18 vs 36

36 vs 72

6 h vs 24 h

Sp-Fr vs Ja-Hu


Spain (n = 8)

1-6 h

18.5 [15-22]

8.5 [5-14]

5.0 [1-11]

-

<0.001

ND

<0.001

<0.001

24 h

20.0 [18-22]

14.5 [10-18]

12.5 [5-17]

-

<0.001

ND

<0.001


France (n = 8)

1-6 h

17.5 [15-28]

8.0 [5-16]

4.0 [2-10]

-

<0.001

ND

<0.001

24 h

19.5 [18-25]

17.5 [12-22]

5.0 [2-10]

-

<0.001

ND

<0.001


Japan (n = 8)

<0.001

1-6 h

21.5 [18-28]

-

5.0 [1-9]

3.5 [1-6]

ND

NS

<0.001

24 h

25.5 [17-29]

-

13.5 [10-18]

10.0 [2-15]

ND

0.01

<0.001


Hungary (n = 8)

1-6 h

18.5 [15-22]

-

2.0 [1-5]

1.0 [1-5]

ND

NS

<0.001

24 h

20 [15-25]

-

9.5 [5-25]

4.5 [2-10]

ND

<0.001

<0.001


Total (n = 32)

1-6 h

21.5 [15-28]

10.5 [5-16]

5.9 [1-11]

2.5 [1-6]

<0.001

<0.001

<0.001

ND

24 h

22.3 [15-29]

16.0 [10-22]

14.5 [2-25]

9.9 [2-15]

<0.001

<0.001

<0.001

ND


The results are representative of at least three independent trials. NS, not significant; ND, not determined. 0 h, pre-cranberry consumption collection

Howell et al. BMC Infectious Diseases 2010 10:94   doi:10.1186/1471-2334-10-94

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