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Open Access Highly Accessed Commentary

Searching for the elusive typhoid diagnostic

Stephen Baker12*, Michael Favorov3 and Gordon Dougan4

Author Affiliations

1 Oxford University Clinical Research Unit, The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

2 The Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK

3 The International Vaccine Institute, Kwanak-gu, Seoul, Korea

4 The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK

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BMC Infectious Diseases 2010, 10:45  doi:10.1186/1471-2334-10-45

Published: 5 March 2010

Abstract

Typhoid (enteric) fever is still a common disease in many developing countries but current diagnostic tests are inadequate. Studies on pathogenesis and genomics have provided new insight into the organisms that cause enteric fever. Better understanding of the microorganisms explains, in part, why our current typhoid methodologies are limited in their diagnostic information and why developing new strategies may be a considerable challenge. Here we discuss the current position of typhoid diagnostics, highlight the need for technological improvements and suggest potential ways of advancing this area.