Table 1

Summary of Susceptibility Studies: Mice challenged with 1 ID50 after pre-treatment with test agent or control

Test Agent administered 12 h before viral challenge

Fraction infected after Test Agent

Fraction infected after PBS Control

P value

Fold-increase in susceptibility

Osmolality (mOsm/kg)


Methylparaben/propylparaben (0.18%/0.02%) in HEC gel

19/60 (32%)

20/60 (33%)

1

374


Benzyl alcohol (1%) in HEC gel

26/60 (43%)

26/60 (43%)

1

338


Disodium EDTA (0.1%) in HEC gel

59/90 (66%)

52/90 (58%)

0.095

2*

376


Disodium EDTA (0.0186%) in HEC gel

10/60 (17%)

14/60 (23%)

0.49

341


Propylene glycol (10%) in HEC gel

38/60 (63%)

33/60 (55%)

0.46

1,770


Glycerin (10%) in HEC gel

15/60 (25%)

23/60 (38%)

0.17

2*

1,700


Glycerin (30%) in HEC gel

32/59 (54%)

20/59 (34%)

0.04

3

4,280


GML (5%) in K-Y Warming Jelly

59/60 (98%)

28/60 (47%)♦

< 0.0001

> 10

10,100



K-Y Warming Jelly (neat)

57/60 (95%)

< 0.0001

> 9

10,300


GML (5%) colloidal suspension in PBS

48/60 (80%)

33/60 (55%)

0.006

5

329


Propylene glycol (neat)

55/60 (92%)

28/59 (47%)♦

< 0.0001

10

9,990



Polyethylene glycol (PEG-8) (neat)

55/60 (92%)

< 0.0001

10

5,610


♦ Control for both agents in the adjacent column in a three-arm experiment.

* Fold-increases were calculated for these formulations because of their strong, though not statistically significant, trends toward increased susceptibility.

Moench et al. BMC Infectious Diseases 2010 10:331   doi:10.1186/1471-2334-10-331

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