Table 4

Predictive values of the cirrhosis algorithm and of liver biopsy, FibroScan and FibroTest for the prediction of HCV-related severe events occurrence, ANRS CO 13 HEPAVIH cohort of HIV-HCV co-infected patients

HCV-related severe eventsa


Absence (n)

Presence (n)

PPV (%)

NPV (%)


Algorithm* N=987

Absence of cirrhosis

752

4

12.5

99.5

Presence of cirrhosis

203

29

Liver Biopsy N=192

Metavir < F4

161

2

10.3

98.8

Metavir F4

26

3

FibroScan N=806

<12.5KPa

653

4

7.4

99.4

≤ 12.5 KPa

138

11

FibroTest N=718

Metavir < F4

528

7

8.2

98.7

Metavir F4

168

15


* See definition in Methods section; PPV: positive predictive value; NPV negative predictive value

a HCV-related severe events: ascites, varices bleeding, hepatic encephalopathy, hepatocellular carcinoma or HCV-related death

Loko et al. BMC Infectious Diseases 2010 10:303   doi:10.1186/1471-2334-10-303

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