Table 3

Diagnostic accuracy of hyaluronic acid (HA) measurement for significant fibrosis (F≥2), advanced fibrosis (F≥3) and cirrhosis (F4) in our cohort.

Cut-off

TP

FP

TN

FN

(*) Se

(95% CI)

(*) Sp

(95% CI)

(*) PPV

(95% CI)

(*) NPV

(95% CI)

LR+

(95% CI)

LR-

(95% CI)

DOR

(95% CI)













Significant fibrosis (F≥ 2)


430 (ng/mL)

111

71

13

6

94.9

(90.4 - 99.3)

15.5

(7.1 - 23.8)

61.0

(53.6 - 68.7)

68.4

(44.9 - 91.9)

1.12

(1.01 - 1.24)

0.33

(0.14 - 0.78)

3.39

(1.23 - 9.32)

1250 (ng/mL)

67

23

61

50

57.3

(47.9 - 66.7)

72.6

(62.5 - 82.7)

74.4

(64.9 - 84.0)

55.0

(45.2 - 64.7)

2.09

(1.43 - 3.06)

0.59

(0.46 - 0.75)

3.55

(1.9 - 6.5)

1800 (ng/mL)

36

4

80

81

30.8

(21.9 - 39.6)

95.2

(90.1 - 100)

90.0

(79.5 -100)

49.7

(41.7 - 57.7)

6.46

(2.39 - 17.46)

0.73

(0.63 - 0.84)

8.89

(3.02 - 26.13)

Advanced fibrosis (F≥ 3)


687 (ng/mL)

61

88

49

3

95.3

(89.3 - 100)

35.8

(27.4 - 44.2)

40.9

(32.7 - 49.2)

94.2

(86.9 - 100)

1.48

(1.29 - 1.70)

0.13

(0.04 - 0.40)

11.32

(3.37 - 37.99)

1250 (ng/mL)

47

43

94

17

73.4

(61.8 - 85.0)

68.6

(60.5 - 76.7)

52.2

(41.3 - 63.1)

84.7

(77.5 - 91.8)

2.34

(1.75 - 3.12)

0.39

(0.25 - 0.6)

6.04

(3.1 - 11.7)

2290 (ng/mL)

18

7

130

46

28.1

(16.3 - 39.9)

94.9

(90.8 - 98.9)

72.0

(52.4 - 91.6)

73.9

(67.1 - 80.6)

5.50

(2.42 - 12.51)

0.76

(0.63 - 0.91)

7.27

(2.85 - 18.52)

Cirrhosis (F4)


1182 (ng/mL)

22

78

100

1

95.7

(85.1 - 100)

56.2

(48.6 - 63.7)

22.0

(13.4 - 30.6)

99.0

(96.6 - 100)

2.18

(1.81 - 2.63)

0.08

(0.01 - 0.53)

28.21

(3.72 - 213.86)

1320 (ng/mL)

21

63

115

2

91.3

(77.6 - 100)

64.6

(57.3 - 71.9)

25.0

(17.1 - 34.9)

98.3

(95.5 - 100)

2.58

(2.04 - 3.26)

0.13

(0.04 - 0.51)

19.17

(4.4 - 84.4)

2400 (ng/mL)

11

9

169

12

47.8

(25.2 - 70.4)

94.9

(91.4 - 98.4)

55.0

(30.7 - 79.3)

93.4

(89.5 - 97.3)

9.46

(4.40 - 20.36)

0.55

(0.36 - 0.82)

17.21

(5.98 - 49.57)


For each fibrosis stage, we chose a low cut-off at 95% sensitivity (Se) used to predict the absence of the disease and a high cut-off at 95% specificity (Sp) used to predict the presence of the disease.

Abbreviations: TP, true positive cases (correct diagnosis); FP, false positive cases (over-diagnosis); TN, true negative cases (correct diagnosis); FN, false negative cases (missed cases); Se, sensitivity; Sp, specificity; PPV, positive predictive value; NPV, negative predictive value; LR, likelihood ratio; DOR, diagnostic odds ratio; (*): values as percentage (%).

Resino et al. BMC Infectious Diseases 2010 10:244   doi:10.1186/1471-2334-10-244

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