Table 5

Determinants of seropositivity among HPV-18 DNA positive women; Contraceptive, pregnancy, smoking status factors.

Women characteristics

Anti-HPV18

Unadjusted

Final model1

Negative

Positive

%

OR

(95% CI)

OR

(95% CI)


All women

76

103

57.5

Use of hormonal contraceptives

Never

17

14

45.2

1.00

1.00

In the past

19

18

48.7

1.15

(0.44-3.00)

1.15

(0.44-3.00)

Current oral contraceptives

31

63

67.0

2.47

(1.08-5.65)

2.47

(1.08-5.65)

Current injectable

9

8

47.1

1.08

(0.33-3.53)

1.08

(0.33-3.53)

Use of condom

Never

27

41

60.3

1.00

1.00

In the past

33

40

54.8

0.80

(0.41-1.56)

0.87

(0.43-1.74)

Current (last month)

16

22

57.9

0.91

(0.40-2.03)

1.19

(0.51-2.80)

Frequency of condom use

Never or rarely

31

50

61.7

1.00

1.00

Sometimes

10

13

56.5

0.81

(0.32-2.06)

0.80

(0.31-2.11)

Most of the time

15

18

54.6

0.74

(0.33-1.69)

0.93

(0.40-2.17)

Always

19

22

53.7

0.72

(0.34-1.53)

0.80

(0.37-1.76)

Use of condom last sexual intercourse

No

54

75

58.1

1.00

1.00

Yes

22

28

56.0

0.92

(0.47-1.77)

1.23

(0.60-2.56)

Number of pregnancies

0

38

44

53.7

1.00

1.00

1

25

39

60.9

1.35

(0.69-2.62)

1.35

(0.69-2.62)

2

11

13

54.2

1.02

(0.41-2.54)

1.02

(0.41-2.54)

≥ 3

2

7

77.8

3.02

(0.59-15.43)

3.02

(0.59-15.43)

p trend

0.29

0.29

Smoking Status

Never smoked for ≥ 6 months

56

75

57.3

1.00

1.00

Former smoker

3

8

72.7

1.99

(0.51-7.85)

1.99

(0.51-7.85)

Current

17

20

54.1

0.88

(0.42-1.83)

0.88

(0.42-1.83)

Cytology-Hybrid capture, viral load2

Normal/Low viral load

34

45

57.0

1.00

1.00

LSIL-HSIL/Low viral load

4

8

66.7

1.51

(0.42-5.44)

1.51

(0.42-5.44)

Normal/High viral load

12

11

47.8

0.69

(0.27-1.76)

0.69

(0.27-1.76)

LSIL-HSIL/High viral load

24

36

60.0

1.13

(0.57-2.24)

1.13

(0.57-2.24)


NOTE. OR, odds ratio; CI, confidence interval; LSIL, low grade squamous intraepithelial lesion; HSIL, high grade squamous intraepithelial lesion; HPV, human papillomavirus.

1 For each variable considered the final model adjusts for all variables that changed the crude estimate of risk by 15% or more.

Use of hormonal contraceptives: was not adjusted for any co-factors since none of the potential confounders evaluated changed the OR estimates by 15% or more.

Use of condom: was adjusted for use of hormonal contraceptives.

Frequency of condom use: was adjusted for use of hormonal contraceptives.

Use of condom last sexual intercourse: was adjusted for use of hormonal contraceptives.

Number of pregnancies, smoking status and cytology-hybrid capture, viral load: were not adjusted for any co-factors since none of the potential confounders evaluated changed the OR estimates by 15% or more.

2 Low viral load defined as hybrid capture RLU/CO ≤ 30; High viral load defined as hybrid capture RLU/CO > 30.

Porras et al. BMC Infectious Diseases 2010 10:238   doi:10.1186/1471-2334-10-238

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