Table 5

Systematic review of the published studies on prevalence of HPV types in the general population in Italy

percentage of positive in the population


Author

pub year

Area

N

Age

Population

type of test

HR+LR

HR

HPV16

HPV18

HPV16+18

Notes on molecular methods

Notes on possible selection biases


Astori [24]

1997

Udine

197

mean 37.7

women referred to gynaecological clinic for genital complaints, Pap negative

PCR My09/11 and RFLP analysis

20.3

5.1

Ronco [8]

2005

Turin

1000

25-70

Invited in Organized Screening program

PCR-EIA Gp5+/Gp6+ home made

8.8

7.1

2.8

0.1

2.9

Centurioni [6]

2005

Genoa

503

mean 51

Opportunistic screening

PCR Dot blot

15.9

9.1

5.8

14.9

the method is not actual any more

The recruitment started in 1992

Tornesello [25]

2006

Milan and Neaples

207

median 40

asymptomatic attending clinic

PCR home made and direct sequence

19.7

16.9

8.7

0

8.7

Tornesello [26]

2007

Neaples

31

mean 28.9

migrant

PCR nested (MY09-11 follwed by the inner GP5+/6+)followed by sequencing

35.5

25.8

6.4

0

6.4

Ammatuna [9]

2008

Sicily

1006

18-24

random population sample

Linear array HPV genotyping test (Roche)

24.1

17.4

4.5

1.3

5.8

Tornesello [7]

2008

Neaples

115

mean 32.5

Opportunistic screening

Home made Nested PCR followe by direct sequencing

13.9

13.9

6.9

0.9

7.8

Del Prete [27]

2008

Apulia

871

>20; 85% = <50

women referred to hospital gynecologic visit

PCR E1-E2 followed by gel

23.1

19.4

9.6

1.6

10.1

Not clear reason for referral, includes women referred for colposcopy

Agarossi [28]

2009

Italy

9947

15->65; 85% <50

asymptomatic attending clinic

HCII followed by typing with Gp5+/Gp6+ PCR EIA Home made

14.8

4.3

1.5

5.6

no mention of negative control for PCR

the sample includes women with previous positive Pap test

Giovannelli [29]

2009

Sicily

120

88% <40

Migrant attending Clinical visit

PCR-Inno-LiPA

47.8

34.8

7.8

6

13.8

Masia [30]

2009

Sardinia

815

>18; 83% = <45

Counselling for sexual activity or screening program

PCR-EIA Gp5+/Gp6+ home made

31

20.3

8.2

13.5

Verteramo [31]

2009

Rome

857

17-57

asymptomatic attending clinic

PCR MY09/11 (and PCR with 4 pairs of primers to amplifiy E6 and E7 gene) followed by sequencing

31

13.3

4.4

0.8

5.3


Giorgi Rossi et al. BMC Infectious Diseases 2010 10:214   doi:10.1186/1471-2334-10-214

Open Data