Open Access Highly Accessed Research article

Prior immunity helps to explain wave-like behaviour of pandemic influenza in 1918-9

John D Mathews1*, Emma S McBryde2, Jodie McVernon1, Paul K Pallaghy1 and James M McCaw1

Author Affiliations

1 Vaccine and Immunisation Research Group, Melbourne School of Population Health, University of Melbourne, 3010, Victoria, Australia

2 Victorian Infectious Disease Service, Royal Melbourne Hospital, 3050, Victoria, Australia

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BMC Infectious Diseases 2010, 10:128  doi:10.1186/1471-2334-10-128

Published: 25 May 2010

Additional files

Additional file 1:

Figures S1.1 and S1.2. Tables S1, S2, S3, S4. Materials and methods. Supporting text. Social distancing. Demarcation of waves and waning of resistance. Incremental nature of acquired immunity. Possibility of virus variation between waves. Possibility of seasonal changes in bacterial infection. Comments on mortality.

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