Table 2

Regression model predicting aggregate bother among patients with at least one side effect

Independent variables

Corticosteroids

IVIg

Anti-D

Rituximab

Splenectomy


Group Mean (SD)§§

3.73

(0.70)

3.56

(1.00)

3.60

(0.95)

3.46

(1.03)

2.74

(1.09)


Adjusted R2 (N)

0.19

(440)

0.11

(208)

0.32

(128)

0.19

(130)

0.12

(151)


Age

0.03(.00)

-0.06(.00)

-0.01(.00)

-0.13(.01)

0.05(.01)


Frequency of dry bleeds (0 = No bleeds, 1 = bleeds)

0.01(.10)

-0.10(.25)

0.24(.26)

**

0.16(.29)

-0.03(.25)


Time since diagnosis¶

-0.01 (.05)

0.00(.12)

-0.01(.13)

0.07(.17)

0.13(.26)


Gender (0 = Male; 1 = Female)

0.17(.08)

****

0.10(.17)

0.09(.20)

0.06(.21)

0.05(.21)


Longest cycle duration§

-0.07(.04)

-

-

-

-


Typical low platelet count (past year)

0.02(.00)

00(0)

0.25(.00)

*

-0.10(.00)

0.14(.00)


Need to stop or reduce (0 = No, 1 = Yes)

0.15(.06)

**

0.31(.16)

****

0.43(.17)

****

0.34(.21)

****

-


Number of treatment effects

0.35(.01)

****

0.15(.04)

*

0.24(.04)

**

0.23(.04)

**

0.34(.09)

****


Number of ITP treatments (among 5 treatment

-0.04(.02)

-0.11(.05)

-0.04(.06)

0.09(.07)

-0.01(.07)


types)


Other ITP medications in combination (0 = No;

0.08(.07)

0.07(.15)

0.08(.16)

0.00(.18)

-


1 = Yes)


Time since last taking drug/procedure†

0.08(.07)

-0.02(.15)

-0.18(.19)

*

-0.11(.19)

0.01(.16)


Type of physician‡

-0.06(.09)

-0.03(26)

0.11(.27)

0.07(.40)

-0.02(.24)


Frequency of wet bleeds (0 = No bleeds, 1 = bleeds)

-0.03(.07)

0.07(.15)

-0.22(.16)

**

-0.16(.20)

-0.05(.21)


* P <0.05

* *P <0.01

* **P <0.001

* ***P <0.0001

Each model based on patients reporting 1 or more side effect.

† Categorical variable were 0 = Currently taking (Less than 5 years ago in case of splenectomy), 1 = Taken in the past (5 or more years ago in case of splenectomy)

‡ Type of physician referred to generalist or specialist.

¶ Categorical variable were 1 = 6 months to 1 year ago, 2 = 1 to 5 years ago, 3 = 5 or more years ago.

§ Categorical variable were 1 = Less than 1 month, 2 = 1 to 3 months, 3 = 3 to 12 months, 4 = more than 12 months.

§§ Mean based only on patients who reported 1or more treatment effects for a given treatment type. (i.e., coding of 1 for patients with no side effects was not used).

Brown et al. BMC Blood Disorders 2012 12:2   doi:10.1186/1471-2326-12-2

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