Table 3

The association of functional disability with subcortical measure of neurodegeneration.

Unadjusted Odds Ratio (95% CI)

Adjusted Odds Ratio (95% CI)


Mild

Severe

Mild

Severe


Sex

Men

1.00

1.00

1.00

1.00

Women

2.3

(0.9–5.4)

1.9

(0.9–4.1)

3.4

(0.9–12.9)

1.4

(0.5–4.2)

Age at death

<75

1.00

1.00

1.00

1.00

75–84

1.3

(0.4–4.1)

0.7

(0.2–1.9)

1.2

(0.2–7.0)

0.3

(0.1–1.4)

>84

3.3

(1.0–10.9)

4.2

(1.5–12.1)

2.9

(0.5–16.2)

2.4

(1.0–9.2)

Overall effect*

1.7

(1.0–3.0)

2.3

(1.4–3.8)

1.6

(0.7–3.5)

1.7

(0.9–3.2)


SUBCORTICAL PATHOLOGY (Factor present reference absence)


NFT

2.1

(0.8–5.0)

1.6

(0.8–3.6)

Neuronal loss

1.3

(0.5–3.2)

3.0

(1.3–6.6)

1.4

(0.3–5.4)

3.9

(1.2–12.5)

Plaques

0.6

(0.1–2.2)

0.3

(0.1–1.2)

Vascular disease

2.2

(0.2–24.9)

3.3

(0.4–29.1)

Lewy bodies

8.3

(0.9–78.3)

1.8

(0.2–18.6)

8.1

(0.8–87.2)

1.2

(0.1–14.2)

LB in Substantia nigra

Impossible to calculate; 100% predictive


2 test for trend Adjusted for all other effects in the table.

Byford et al. BMC Geriatrics 2009 9:22   doi:10.1186/1471-2318-9-22

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