Table 3 |
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|
The association of functional disability with subcortical measure of neurodegeneration. |
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|
Unadjusted Odds Ratio (95% CI) |
Adjusted Odds Ratio (95% CI)† |
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|
|
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|
Mild |
Severe |
Mild |
Severe |
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|
|
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|
Sex |
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|
Men |
1.00 |
1.00 |
1.00 |
1.00 |
||||
|
Women |
2.3 |
(0.9–5.4) |
1.9 |
(0.9–4.1) |
3.4 |
(0.9–12.9) |
1.4 |
(0.5–4.2) |
|
Age at death |
||||||||
|
<75 |
1.00 |
1.00 |
1.00 |
1.00 |
||||
|
75–84 |
1.3 |
(0.4–4.1) |
0.7 |
(0.2–1.9) |
1.2 |
(0.2–7.0) |
0.3 |
(0.1–1.4) |
|
>84 |
3.3 |
(1.0–10.9) |
4.2 |
(1.5–12.1) |
2.9 |
(0.5–16.2) |
2.4 |
(1.0–9.2) |
|
Overall effect* |
1.7 |
(1.0–3.0) |
2.3 |
(1.4–3.8) |
1.6 |
(0.7–3.5) |
1.7 |
(0.9–3.2) |
|
|
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|
SUBCORTICAL PATHOLOGY (Factor present reference absence) |
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|
|
||||||||
|
NFT |
2.1 |
(0.8–5.0) |
1.6 |
(0.8–3.6) |
||||
|
Neuronal loss |
1.3 |
(0.5–3.2) |
3.0 |
(1.3–6.6) |
1.4 |
(0.3–5.4) |
3.9 |
(1.2–12.5) |
|
Plaques |
0.6 |
(0.1–2.2) |
0.3 |
(0.1–1.2) |
||||
|
Vascular disease |
2.2 |
(0.2–24.9) |
3.3 |
(0.4–29.1) |
||||
|
Lewy bodies |
8.3 |
(0.9–78.3) |
1.8 |
(0.2–18.6) |
8.1 |
(0.8–87.2) |
1.2 |
(0.1–14.2) |
|
LB in Substantia nigra |
Impossible to calculate; 100% predictive |
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|
|
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|
*χ2 test for trend † Adjusted for all other effects in the table. |
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|
Byford et al. BMC Geriatrics 2009 9:22 doi:10.1186/1471-2318-9-22 |
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