Table 3 |
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|
Validity of Mindstreams tests in discriminating mild cognitive impairment (MCI; N = 20) from cognitively healthy elderly (N = 15) as compared with traditional paper-based tests of the same cognitive domains. |
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|
Cognitive Domain |
Mindstreams Test (outcome parameter) |
AUC |
SE |
Asymptotic Significance |
95% CI |
Traditional Measure |
AUC |
SE |
Asymptotic Significance |
95% CI |
|
|
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|
MEMORY |
Verbal Memory (accuracy, first repetition trial) |
0.848 |
0.066 |
0.001 |
0.719–0.977 |
WMS-III Logical Memory I |
0.800 |
0.076 |
0.003 |
0.650–0.950 |
|
Verbal Memory (accuracy, second repetition trial) |
0.831 |
0.071 |
0.001 |
0.692–0.971 |
WMS-III Logical Memory II |
0.885 |
0.055 |
0.000 |
0.778–0.992 |
|
|
Verbal Memory (accuracy, third repetition trial) |
0.720 |
0.089 |
0.031 |
0.547–0.894 |
RAVLT Immediate Recall A |
0.632 |
0.096 |
0.188 |
0.443–0.820 |
|
|
Verbal Memory Accuracy (accuracy, final repetition trial) |
0.752 |
0.086 |
0.014 |
0.583–0.920 |
RAVLT Total |
0.833 |
0.068 |
0.001 |
0.701–0.966 |
|
|
Verbal Memory (accuracy, all repetition trials) |
0.894 |
0.056 |
0.000 |
0.785–1.000 |
RAVLT Immediate Recall B |
0.688 |
0.091 |
0.06 |
0.510–0.866 |
|
|
Verbal Memory (accuracy, delayed recognition) |
0.748 |
0.085 |
0.015 |
0.582–0.914 |
RAVLT Short Term Retention |
0.874 |
0.062 |
0.000 |
0.752–0.995 |
|
|
Non-Verbal Memory (accuracy, first repetition trial) |
0.654 |
0.097 |
0.127 |
0.464–0.844 |
RAVLT Delayed Recall |
0.846 |
0.073 |
0.001 |
0.702–0.990 |
|
|
Non-Verbal Memory (accuracy, second repetition trial) |
0.681 |
0.095 |
0.074 |
0.494–0.867 |
RAVLT Recognition |
0.823 |
0.073 |
0.001 |
0.680–0.965 |
|
|
Non-Verbal Memory (accuracy, third repetition trial) |
0.642 |
0.097 |
0.160 |
0.453–0.831 |
||||||
|
Non-Verbal Memory Accuracy (accuracy, final repetition trial) |
0.686 |
0.093 |
0.066 |
0.505–0.867 |
||||||
|
Non-Verbal Memory (accuracy, all repetition trials) |
0.719 |
0.090 |
0.030 |
0.542–0.897 |
||||||
|
Non-Verbal Memory (accuracy, delayed recognition) |
0.684 |
0.094 |
0.069 |
0.499–0.869 |
||||||
|
|
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|
EXECUTIVE FUNCTION |
Go-NoGo (accuracy) |
0.742 |
0.088 |
0.019 |
0.570–0.915 |
Clock Drawing |
0.680 |
0.092 |
0.072 |
0.499–0.861 |
|
Go-NoGo (performance index) |
0.840 |
0.069 |
0.001 |
0.705–0.976 |
Trail Making Test A |
0.660 |
0.092 |
0.11 |
0.479–0.841 |
|
|
Problem Solving (accuracy) |
0.685 |
0.098 |
0.077 |
0.492–0.877 |
WAIS-III Digit Symbol |
0.729 |
0.091 |
0.03 |
0.550–0.908 |
|
|
WMS-III Mental Control |
0.706 |
0.092 |
0.05 |
0.525–0.888 |
||||||
|
|
||||||||||
|
VISUAL SPATIAL |
Visual Spatial Imagery (accuracy) |
0.778 |
0.079 |
0.007 |
0.622–0.934 |
WAIS-III Block Design |
0.599 |
0.102 |
0.347 |
0.400–0.798 |
|
|
||||||||||
|
VERBAL |
Verbal Function (accuracy, naming) |
0.777 |
0.085 |
0.009 |
0.610–0.944 |
Boston Naming Test |
0.747 |
0.082 |
0.014 |
0.585–0.908 |
|
Verbal Function (accuracy, rhyming) |
0.837 |
0.070 |
0.001 |
0.700–0.973 |
COWA FS |
0.768 |
0.081 |
0.008 |
0.609–0.928 |
|
|
COWA A |
0.739 |
0.086 |
0.018 |
0.570–0.907 |
||||||
|
COWA Animals |
0.711 |
0.088 |
0.037 |
0.538–0.883 |
||||||
|
WAIS-III Similarities |
0.553 |
0.11 |
0.618 |
0.337–0.768 |
||||||
|
|
||||||||||
|
Mindstreams outcome parameters with insufficient data (<13 data points per group) due to failed practice sessions (see Methods) were excluded. AUC = area under the curve WMS-III = Wechsler Memory Scale, 3rd edition SE = standard error RAVLT = Rey Auditory Verbal Learning Test, Version 1 CI = confidence interval WAIS-III = Wechsler Adult Intelligence Scale, 3rd Edition RT = reaction time COWA = Controlled Oral Word Association |
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|
Dwolatzky et al. BMC Geriatrics 2003 3:4 doi:10.1186/1471-2318-3-4 |
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