Table 3

Validity of Mindstreams tests in discriminating mild cognitive impairment (MCI; N = 20) from cognitively healthy elderly (N = 15) as compared with traditional paper-based tests of the same cognitive domains.

Cognitive Domain

Mindstreams Test (outcome parameter)

AUC

SE

Asymptotic Significance

95% CI

Traditional Measure

AUC

SE

Asymptotic Significance

95% CI


MEMORY

Verbal Memory (accuracy, first repetition trial)

0.848

0.066

0.001

0.719–0.977

WMS-III Logical Memory I

0.800

0.076

0.003

0.650–0.950

Verbal Memory (accuracy, second repetition trial)

0.831

0.071

0.001

0.692–0.971

WMS-III Logical Memory II

0.885

0.055

0.000

0.778–0.992

Verbal Memory (accuracy, third repetition trial)

0.720

0.089

0.031

0.547–0.894

RAVLT Immediate Recall A

0.632

0.096

0.188

0.443–0.820

Verbal Memory Accuracy (accuracy, final repetition trial)

0.752

0.086

0.014

0.583–0.920

RAVLT Total

0.833

0.068

0.001

0.701–0.966

Verbal Memory (accuracy, all repetition trials)

0.894

0.056

0.000

0.785–1.000

RAVLT Immediate Recall B

0.688

0.091

0.06

0.510–0.866

Verbal Memory (accuracy, delayed recognition)

0.748

0.085

0.015

0.582–0.914

RAVLT Short Term Retention

0.874

0.062

0.000

0.752–0.995

Non-Verbal Memory (accuracy, first repetition trial)

0.654

0.097

0.127

0.464–0.844

RAVLT Delayed Recall

0.846

0.073

0.001

0.702–0.990

Non-Verbal Memory (accuracy, second repetition trial)

0.681

0.095

0.074

0.494–0.867

RAVLT Recognition

0.823

0.073

0.001

0.680–0.965

Non-Verbal Memory (accuracy, third repetition trial)

0.642

0.097

0.160

0.453–0.831

Non-Verbal Memory Accuracy (accuracy, final repetition trial)

0.686

0.093

0.066

0.505–0.867

Non-Verbal Memory (accuracy, all repetition trials)

0.719

0.090

0.030

0.542–0.897

Non-Verbal Memory (accuracy, delayed recognition)

0.684

0.094

0.069

0.499–0.869


EXECUTIVE FUNCTION

Go-NoGo (accuracy)

0.742

0.088

0.019

0.570–0.915

Clock Drawing

0.680

0.092

0.072

0.499–0.861

Go-NoGo (performance index)

0.840

0.069

0.001

0.705–0.976

Trail Making Test A

0.660

0.092

0.11

0.479–0.841

Problem Solving (accuracy)

0.685

0.098

0.077

0.492–0.877

WAIS-III Digit Symbol

0.729

0.091

0.03

0.550–0.908

WMS-III Mental Control

0.706

0.092

0.05

0.525–0.888


VISUAL SPATIAL

Visual Spatial Imagery (accuracy)

0.778

0.079

0.007

0.622–0.934

WAIS-III Block Design

0.599

0.102

0.347

0.400–0.798


VERBAL

Verbal Function (accuracy, naming)

0.777

0.085

0.009

0.610–0.944

Boston Naming Test

0.747

0.082

0.014

0.585–0.908

Verbal Function (accuracy, rhyming)

0.837

0.070

0.001

0.700–0.973

COWA FS

0.768

0.081

0.008

0.609–0.928

COWA A

0.739

0.086

0.018

0.570–0.907

COWA Animals

0.711

0.088

0.037

0.538–0.883

WAIS-III Similarities

0.553

0.11

0.618

0.337–0.768


Mindstreams outcome parameters with insufficient data (<13 data points per group) due to failed practice sessions (see Methods) were excluded. AUC = area under the curve WMS-III = Wechsler Memory Scale, 3rd edition SE = standard error RAVLT = Rey Auditory Verbal Learning Test, Version 1 CI = confidence interval WAIS-III = Wechsler Adult Intelligence Scale, 3rd Edition RT = reaction time COWA = Controlled Oral Word Association

Dwolatzky et al. BMC Geriatrics 2003 3:4   doi:10.1186/1471-2318-3-4

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