Table 7

Secondary outcomes continued: neuroimaging




Structural MRI: T1-weighted

Whole Brain Measures

1. Voxel Based Morphometry

A combination of different software packages will be used for automated and semi-automated computational neuroanatomical analyses, in addition to expert manual tracing of hippocampus and entorhinal cortex.

2. Cortical thickness

3. Whole brain volume

4. GM volume

5. WM volume

6. CSF volume

Regional Measures

1. Automated regional cortical volume measures

2. Manually traced subcortical volumes

FLAIR-weighted MRI

White matter hyperintensity volume

Automated measure of white matter disease load

Magnetic Resonance Spectroscopy (MRS)

Relative measures of :

1. N-acetylaspartate (NAA)

Measures of different brain metabolites using MR spectroscopy in the hippocampus and posterior cingulate grey matter.

2. Cholines

3. Myo-inositol

4. Creatine+Phosphocreatine

Resting State functional MRI

1. Bilateral hippocampal connectivity

Seed-based correlational analysis and Independent Component Analysis will be used to characterise individuals' resting state BOLD time series.

2. Hippocampus functional connectivity map

3. Posterior cingulate functional connectivity map

4. Default Mode Network (DMN)

5. DMN-anticorrelations

Gates et al. BMC Geriatrics 2011 11:19   doi:10.1186/1471-2318-11-19

Open Data