A. Colonic biopsy with GVHD- Focal crypt abnormalities (crypt size variation and irregular crypt distribution) with decreased mucosal thickness (x). Inset: Ectatic vessels (y) and slightly dilated crypt (z) with mild decrease in number of lymphocytes in LP. B. Colonic biopsy with GVHD (higher magnification of area adjacent to 'x' in figure 2A) – Crypt abnormalities with focal ulceration (A), focal reactive surface epithelium (b), focal fibrosis (C), and many apoptotic cells in crypts (d).
Shidham et al. BMC Gastroenterology 2003 3:5 doi:10.1186/1471-230X-3-5