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Open Access Highly Accessed Correspondence

A proposal for a new clinical classification of chronic pancreatitis

Markus W Büchler1*, Marc E Martignoni2, Helmut Friess2 and Peter Malfertheiner3

Author Affiliations

1 Department of General Surgery, University of Heidelberg, Germany

2 Department of Surgery, Technical University Munich, Germany

3 Department of Gastroenterology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany

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BMC Gastroenterology 2009, 9:93  doi:10.1186/1471-230X-9-93

Published: 14 December 2009

Abstract

Background

The clinical course of chronic pancreatitis is still unpredictable, which relates to the lack of the availability of a clinical classification. Therefore, patient populations cannot be compared, the course and the outcome of the disease remain undetermined in the individual patient, and treatment is not standardized.

Aim

To establish a clinical classification for chronic pancreatitis which is user friendly, transparent, relevant, prognosis- as well as treatment-related and offers a frame for future disease evaluation.

Methods

Diagnostic requirements will include one clinical criterion, in combination with well defined imaging or functional abnormalities.

Results

A classification system consisting of three stages (A, B and C) is presented, which fulfils the above-mentioned criteria. Clinical criteria are: pain, recurrent attacks of pancreatitis, complications of chronic pancreatitis (e.g. bile duct stenosis), steatorrhea, and diabetes mellitus. Imaging criteria consist of ductal or parenchymal changes observed by ultrasonography, ERCP, CT, MRI, and/or endosonography.

Conclusion

A new classification of chronic pancreatitis, based on combination of clinical signs, morphology and function, is presented. It is easy to handle and an instrument to study and to compare the natural course, the prognosis and treatment of patients with chronic pancreatitis.