Table 1 |
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Development of metaplasia and squamous cell carcinoma in mouse esophagus due to gastroesophageal reflux |
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Week 20 |
Week 40 |
Week 80 |
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Group |
Genotype |
Treatment |
Metaplasia |
Metaplasia |
Squamous cell carcinoma |
Squamous cell carcinoma |
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|
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A |
Wild-type |
Non-operated control |
0/10 |
0/10 |
0/10 |
- |
|
B |
Wild-type |
Reflux surgery and 50 mg/kg/m Fe, i.p. (Wk 41 to 80) |
1/20 (5%) |
6/37 (16.2%) |
0/37 |
12/13 (92.3%) |
|
C |
p53A135V |
Reflux surgery |
1/19 (5.3%) |
2/42 (4.8%) |
0/42 |
- |
|
D |
INK4a/Arf+/- |
Reflux surgery |
0/10 |
0/14 |
1/14 (7.1%) |
- |
|
E |
Wild-type |
Reflux surgery, omeprazole (1,400 ppm) and 50 mg/kg/m Fe, i.p. (Wk 21 to 40) |
- |
0/11 |
0/11 |
|
|
F |
Wild-type |
Reflux surgery and 50 mg/kg/m Fe, i.p. (Wk 2 to 40) |
- |
0/22 |
0/22 |
- |
|
G |
Wild-type |
Reflux surgery, gastrectomy and 50 mg/kg/m Fe, i.p. (Wk 2 to 40) |
- |
1/14 (6.7%) |
3/14a (21.4%) |
- |
|
|
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a Compared with Group B (P < 0.05) |
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Hao et al. BMC Gastroenterology 2009 9:59 doi:10.1186/1471-230X-9-59 |
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