Table 2

Clinical characteristics of latent CD – patient chart review.

EMA;

N = 38

AGA;

N = 36

TTGA;

N = 38

Total;

N = 112

Total Weighted

N = 3,736


Background data


Females

26 (68)

24 (67)

25 (66)

75 (67)

-


Age at first biopsy: median, range (years)

13 (2–80)

34 (1–91)

34 (1–75)

29 (1–91)

-


Year of biopsy, median*

2003

2001

2006

2004

-


Reported heredity for CD

12 (32)

7 (19)

6 (16)

25 (22)

20%


Other diseases


Diabetes Mellitus, type 1

3 (8)

1 (3)

4 (10)

8 (7)

3%


Depression

1 (3)

4 (11)

8 (21)

13 (12)

11%


Thyroid disease

2 (5)

3 (8)

7 (18)

12 (11)

9%


Liver disease or increased liver enzymes

3 (8)

4 (11)

4 (10)

11 (10)

11%


Symptoms


Any gastrointestinal symptom#

31 (82)

32 (89)

32 (84)

95 (85)

88%


Diarrhea

16 (42)

18 (50)

17 (45)

51 (46)

49%


Weight loss/growth failure

9 (24)

7 (20)

7 (18)

23 (20)

20%


Abdominal pain

14 (37)

18 (50)

18 (47)

50 (45)

49%


Constipation

10 (26)

4 (11)

6 (16)

20 (18)

12%


Fatigue

6 (16)

6 (17)

5 (13)

17 (15)

16%


Laboratory data


Anemia and/or iron-deficiency

5 (13)

12 (33)

12 (32)

29 (26)

32%


Folic acid deficiency

2 (5)

0 (0)

4 (10)

6 (5)

1%


B12-deficiency

4 (10)

2 (6)

5 (13)

11 (10)

6%


Erythrocyte sedimentation rate, increased

0 (0)

2 (6)

3 (8)

5 (4)

5%


Percentages are given within brackets. Although latent CD was evaluated in 120 individuals, data on symptoms and signs (± laboratory measures) were only available in 112 individuals (93.3%).

EMA = Endomysial antibodies. AGA = Antigliadin antibodies. TTGA = Tissue transglutaminase antibodies.

Weighted percentages were estimated to mirror the full sample of study participants.

*Only for year of biopsy was there a statistically significant difference according to CD serology subtype when we corrected for multiple testing (Bonferroni correction [20]. There was no statistically significant difference in prevalence of any symptom or sign according to CD serology subtype.

#Weight loss was included among "any GI symptom". Also reflux symptoms (not listed above); nausea and abdominal gases were included among "any GI symptoms".

Additional information: Two individuals had a diagnosis of inflammatory bowel disease (IBD), both were positive for TTGA. Another two individuals had a diagnosis of dermatitis herpetiformis, both were positive for EMA.

Ludvigsson et al. BMC Gastroenterology 2009 9:57   doi:10.1186/1471-230X-9-57

Open Data