Figure 1.

Cells submitted to FISH (A) and immunohistochemistry (B) assays. A1 (case 14), A2 (case 5) and A3 (case 6): interphase nuclei presenting chr17 monosomy (green signal) with one copy of TP53 (red signal), and nuclei presenting chr17 disomy with one or two copies of TP53 – 1000× magnification; B1 (case 14) and B2 (case 17): tissue with nuclear p53 immunoreactivity (brown stain) – 400× and 100× magnification, respectively; B3 (case 6): tissue without p53 immunoreactivity – 400× magnification.