Open Access Open Badges Research article

Quality of life following liver transplantation: a comparative study between Familial Amyloid Neuropathy and liver disease patients

Diogo Telles-Correia12*, Helena Cortez-Pinto3, António Barbosa1, Inês Mega2 and Estela Monteiro23

Author Affiliations

1 Department of Psychiatry, Faculty of Medicine, University of Lisbon, Portugal

2 Psychiatric approach to Liver Transplanted Patients' Unit of Curry Cabral Hospital's Liver Transplantation Center, Lisbon, Portugal

3 Department of Gastroenterology, Faculty of Medicine, University of Lisbon, Portugal

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BMC Gastroenterology 2009, 9:54  doi:10.1186/1471-230X-9-54

Published: 15 July 2009



It has been demonstrated in many studies that quality of life can be improved after liver transplantation in patients with liver disease. Nevertherless quality of life improvement in specific groups of transplantated patients such as those with Familial Amyloid Polineuropathy hasn't yet been explored. The present study aimed to compare the change in quality of life following liver transplantation between patients with Familial Amyloid Polineuropathy (FAP) and patients with liver disease.


Patient's mental quality of life showed an improvement in all liver disease patients, and a worsening in FAP patients, resulting in a significant difference between the two groups. Regarding physical quality of life, although a similar improvement was seen in both groups, FAP patients had significantly less improvement than the sub-group of decompensated liver disease (Child-Pugh B and C).


It is concluded that liver transplantation has a less beneficial impact in FAP patient's physical quality of life, probably because they are not so much disabled by their disease at the moment of liver transplantation. The lesser improvement in mental quality of life of FAP patients may be due to their particular psychological profile and greater expectations towards transplantation.