Table 4

The expression patterns for GATA-4, GATA-6 and Ihh in gastrointestinal neoplasias

Tissue

Diagnosis

GATA-4

GATA-6

Ihh


Esophagus (n = 9)

Barrett's esophagus

+++

+++

++

Stomach (n = 8)

Intestinal metaplasia

+++

+++

++

Neuroendocrine cell hyperplasia

++

+++

-

Colon (n = 15)

Adenoma, low grade dysplasia

-

+

+

Adenoma, high grade dysplasia

-

++

++

Adenocarcinoma, low/moderate grade

-

+

-

Adenocarcinoma, high grade

-

+

-


The expression patterns are based on the number of positive cells detected and the intensity of staining:

- no expression

+ individual positive cells or small areas with low expression

++ patches of moderate expression

+++ large areas of moderate or strong expression

Haveri et al. BMC Gastroenterology 2008 8:9   doi:10.1186/1471-230X-8-9

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