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Open Access Highly Accessed Case report

Metastases from renal cell carcinoma presenting as gastrointestinal bleeding: two case reports and a review of the literature

Gareth J Sadler1*, Mark R Anderson1, Mark S Moss2 and Paul G Wilson1

Author affiliations

1 Department of Gastroenterology, City Hospital, Dudley Road, Birmingham B18 7QH, UK

2 Department of Radiology, City Hospital, Dudley Road, Birmingham B18 7QH, UK

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Citation and License

BMC Gastroenterology 2007, 7:4  doi:10.1186/1471-230X-7-4

Published: 31 January 2007

Abstract

Background

Bleeding from small bowel neoplasms account for 1–4% of cases of upper gastrointestinal haemorrhage. Renal cell carcinoma constitutes 3% of all adult malignancies and often presents insidiously. Consequently 25–30% of patients have metastases at the time of diagnosis. Gastrointestinal bleeding from renal cell carcinoma metastases is an uncommon and under-recognised manifestation of this disease.

Case Report

In this report we describe two cases of gastrointestinal bleeding from renal cell carcinoma metastases – in one patient bleeding heralded the primary manifestation of disease and in the other signified recurrence of disease following nephrectomy.

Conclusion

These cases highlight the importance endoscopic vigilance in cases of undiagnosed upper gastrointestinal haemorrhage, especially in patients with a past history of renal cell carcinoma.