Hepatic uPA activation occurs in the absence of uPAR. Activation of uPA in the liver was observed in mice of all genotypes after CCl4, except in uPA° mice. The upper band (arrow) depicts tPA while the lower band (arrow head) depicts uPA.
Shanmukhappa et al. BMC Gastroenterology 2006 6:40 doi:10.1186/1471-230X-6-40