Figure 6.

Receptor-free uPA is required for fibrin clearance. Detection of fibrin deposition by immunohistochemistry (red stain, arrows) shows uniform staining in centrilobular area in livers of mice of all genotypes 2 days after CCl₄. The clearance of fibrin coincides with the resolution of the centrilobular injury by day 14 in mice of each genotype, except for uPA° mice. (Magnification 200×)