Table 3

Univariate and multivariate predictors of NASH in the overall population (training and validation groups together)

Characteristic

No NASH vs Borderline or NASH

NASH vs Borderline or No NASH


No NASH n = 98

Borderline NASH n = 96

NASH n = 63

Univariate analysis P-value

Multivariate analysis P value

Odds Ratio (95% CI)

Univariate analysis P-value

Multivariate analysis P value

Odds Ratio (95% CI)


Demographics

Age at biopsy, years

49.4 (1.2)

51.4 (1.2)

53.8 (1.5)

0.045

0.75

1.00 (0.97;1.04)

0.04

0.99

1.00 (0.97;1.33)

Male gender

56/98 (57%)

66/96 (69%)

31/63 (49%)

0.54

0.82

1.10 (0.48;2.56)

0.054

0.04

2.54 (1.03;6.26)

Weight, kg

75.2 (1.4)

86.8 (1.4)

82.3 (1.8)

< 0.0001

< 0.0001

1.06 (1.03;1.08)

0.25

0.86

1.00 (0.97;1.02)

Height, meter

1.68 (0.01)

1.69 (0.01)

1.67 (0.01)

0.87

0.15

0.03 (0.00;3.34)

0.22

0.66

0.33 (0.00;47.2)

Biochemical markers

α2-macroglobulin, g/L

1.58 (0.07)

1.73 (0.07)

1.86 (0.08)

0.02

0.15

0.33 (0; 1050)

0.01

0.16

0.72 (0.46;1.14)

ALT, IU/L

67 (5)

74 (5)

88 (6)

0.005

0.90

1.00 (0.99;1.01)

0.004

0.24

0.99 (0.99;1.00)

AST, IU/L

40 (3)

48 (3)

60 (4)

0.0004

0.007

1.02 (1.01;1.04)

0.001

0.25

0.99 (0.98;1.01)

Apolipoprotein A1, g/L

1.61 (0.05)

1.43 (0.05)

1.50 (0.06)

0.08

0.27

0.53 (0.17;1.67)

0.62

0.71

1.14 (0.57;2.28)

Haptoglobin, g/L

1.14 (0.10)

1.11 (0.07)

1.02 (0.09)

0.87

0.50

0.83 (0.47;1.44)

0.41

0.18

1.56 (0.81;2.99)

GGT, IU/L

133 (14)

98 (14)

128 (17)

0.002

0.005

1.00 (0.993;0.998)

0.48

0.37

1.00 (0.998;1.00)

Total bilirubin, μmol/L

11.2 (0.6)

12.0 (0.6)

12.5 (0.8)

0.87

0.22

1.04 (0.98;1.09)

0.30

0.35

0.98 (0.93;1.02)

Glucose mmol/L

5.5 (0.2)

6.0 (0.2)

7.2 (0.3)

0.005

0.05

1.20 (0.999;1.45)

< 0.0001

0.0009

0.77 (0.67;0.90)

Cholesterol mmol/L

5.4 (0.1)

5.5 (0.1)

5.4 (0.2)

0.68

0.25

1.17 (0.90;1.53)

0.77

0.95

1.01 (0.78;1.30)

Triglycerides

1.4 (0.2)

2.0 (0.2)

2.0 (0.2)

< 0.0001

0.23

1.19 (0.90;1.57)

0.007

0.90

1.01 (0.83;1.24)

FibroTest

0.25 (0.02)

0.31 (0.01)

0.35 (0.02)

0.03

Not included

Not included

0.008

Not included

Not included

SteatoTest

0.60 (0.02)

0.70 (0.02)

0.72 (0.03)

< 0.0001

Not included

Not included

0.007

Not included

Not included


All data are means (se) and proportions (n [%]). ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyl-transpeptidase.

Poynard et al. BMC Gastroenterology 2006 6:34   doi:10.1186/1471-230X-6-34

Open Data