Table 2

Univariate predictors of NASH in training and validation groups

Characteristic

Training Group

Validation Group


No NASH n = 57

Borderline NASH n = 75

NASH n = 28

P-value

No NASH n = 41

Borderline NASH n = 21

NASH n = 35

P-value


Demographics

Age at biopsy, years

53.7 (1.5)

52.6 (1.3)

54.2 (2.1)

0.80

44.8 (1.8)

47.3 (2.8)

53.6 (2.1)

0.008

Male gender

35 (61%)

49 (65%)

12 (43%)

0.11

21 (51%)

17 (81%)

19 (54%)

0.06

Weight, kg

79.3 (1.9)

86.8 (1.69)

83.9 (2.8)

0.02

69.7 (2.0)

86.6 (2.78)

81.1 (2.15)

< 0.0001

Height, meter

1.69 (0.01)

1.68 (0.01)

1.66 (0.02)

0.54

1.67 (0.01)

1.74 (0.02)

1.68 (0.02)

0.02

Biochemical markers

α2-macroglobulin, g/L

1.61 (0.09)

1.69 (0.08)

1.90 (0.13)

0.18

1.54 (0.10)

1.87 (0.14)

1.83 (0.11)

0.06

ALT, IU/L

61 (6)

78 (5)

81 (8)

0.03

75 (8)

60 (10)

94 (8)

0.03

AST, IU/L

42 (4)

53 (4)

57 (6)

0.06

37 (4)

32 (6)

62 (5)

< 0.0001

Apolipoprotein A1, g/L

1.54 (0.04)

1.41 (0.04)

1.49 (0.06)

0.08

1.71 (0.10)

1.48 (0.15)

1.51 (0.11)

0.32

Haptoglobin, g/L

1.08 (0.07)

1.14 (0.06)

1.01 (0.10)

0.52

1.24 (0.15)

1.02 (0.21)

1.04 (0.16)

0.56

GGT, IU/L

107 (19)

103 (17)

139 (28)

0.54

169 (18)

78 (26)

120 (20)

0.02

Total bilirubin, μmol/L

10.6 (0.9)

11.9 (0.7)

11.6 (1.2)

0.50

12.0 (0.89)

12.6 (1.24)

13.2 (0.96)

0.69

Glucose mmol/L

5.7 (0.3)

6.1 (0.3)

7.0 (0.4)

0.051

5.2 (0.31)

5.8 (0.44)

7.3 (0.34)

< 0.0001

Cholesterol mmol/L

5.5 (0.2)

5.4 (0.2)

5.5 (0.2)

0.98

5.4 (0.21)

5.62 (0.29)

5.25 (0.23)

0.61

Triglycerides

1.6 (0.2)

2.1 (0.2)

2.4 (0.4)

0.16

1.15 (0.11)

1.52 (0.16)

1.67 (0.12)

0.008

FibroTest

0.26 (0.03)

0.31 (0.02)

0.35 (0.04)

0.18

0.23 (0.03)

0.32 (0.04)

0.35 (0.03)

0.02

SteatoTest

0.64 (0.02)

0.72 (0.02)

0.75 (0.03)

0.007

0.54 (0.03)

0.61 (0.05)

0.69 (0.04)

0.02


All data are means (se) and proportions (n [%]). ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyl-transpeptidase.

Poynard et al. BMC Gastroenterology 2006 6:34   doi:10.1186/1471-230X-6-34

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