Table 2 |
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|
Univariate predictors of NASH in training and validation groups |
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|
Characteristic |
Training Group |
Validation Group |
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|
|
||||||||
|
No NASH n = 57 |
Borderline NASH n = 75 |
NASH n = 28 |
P-value |
No NASH n = 41 |
Borderline NASH n = 21 |
NASH n = 35 |
P-value |
|
|
|
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|
Demographics |
||||||||
|
Age at biopsy, years |
53.7 (1.5) |
52.6 (1.3) |
54.2 (2.1) |
0.80 |
44.8 (1.8) |
47.3 (2.8) |
53.6 (2.1) |
0.008 |
|
Male gender |
35 (61%) |
49 (65%) |
12 (43%) |
0.11 |
21 (51%) |
17 (81%) |
19 (54%) |
0.06 |
|
Weight, kg |
79.3 (1.9) |
86.8 (1.69) |
83.9 (2.8) |
0.02 |
69.7 (2.0) |
86.6 (2.78) |
81.1 (2.15) |
< 0.0001 |
|
Height, meter |
1.69 (0.01) |
1.68 (0.01) |
1.66 (0.02) |
0.54 |
1.67 (0.01) |
1.74 (0.02) |
1.68 (0.02) |
0.02 |
|
Biochemical markers |
||||||||
|
α2-macroglobulin, g/L |
1.61 (0.09) |
1.69 (0.08) |
1.90 (0.13) |
0.18 |
1.54 (0.10) |
1.87 (0.14) |
1.83 (0.11) |
0.06 |
|
ALT, IU/L |
61 (6) |
78 (5) |
81 (8) |
0.03 |
75 (8) |
60 (10) |
94 (8) |
0.03 |
|
AST, IU/L |
42 (4) |
53 (4) |
57 (6) |
0.06 |
37 (4) |
32 (6) |
62 (5) |
< 0.0001 |
|
Apolipoprotein A1, g/L |
1.54 (0.04) |
1.41 (0.04) |
1.49 (0.06) |
0.08 |
1.71 (0.10) |
1.48 (0.15) |
1.51 (0.11) |
0.32 |
|
Haptoglobin, g/L |
1.08 (0.07) |
1.14 (0.06) |
1.01 (0.10) |
0.52 |
1.24 (0.15) |
1.02 (0.21) |
1.04 (0.16) |
0.56 |
|
GGT, IU/L |
107 (19) |
103 (17) |
139 (28) |
0.54 |
169 (18) |
78 (26) |
120 (20) |
0.02 |
|
Total bilirubin, μmol/L |
10.6 (0.9) |
11.9 (0.7) |
11.6 (1.2) |
0.50 |
12.0 (0.89) |
12.6 (1.24) |
13.2 (0.96) |
0.69 |
|
Glucose mmol/L |
5.7 (0.3) |
6.1 (0.3) |
7.0 (0.4) |
0.051 |
5.2 (0.31) |
5.8 (0.44) |
7.3 (0.34) |
< 0.0001 |
|
Cholesterol mmol/L |
5.5 (0.2) |
5.4 (0.2) |
5.5 (0.2) |
0.98 |
5.4 (0.21) |
5.62 (0.29) |
5.25 (0.23) |
0.61 |
|
Triglycerides |
1.6 (0.2) |
2.1 (0.2) |
2.4 (0.4) |
0.16 |
1.15 (0.11) |
1.52 (0.16) |
1.67 (0.12) |
0.008 |
|
FibroTest |
0.26 (0.03) |
0.31 (0.02) |
0.35 (0.04) |
0.18 |
0.23 (0.03) |
0.32 (0.04) |
0.35 (0.03) |
0.02 |
|
SteatoTest |
0.64 (0.02) |
0.72 (0.02) |
0.75 (0.03) |
0.007 |
0.54 (0.03) |
0.61 (0.05) |
0.69 (0.04) |
0.02 |
|
|
||||||||
|
All data are means (se) and proportions (n [%]). ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyl-transpeptidase. |
||||||||
|
Poynard et al. BMC Gastroenterology 2006 6:34 doi:10.1186/1471-230X-6-34 |
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