IL-10 gene transfer blocked TNF-α induced lymphocyte adhesion on SVEC. TNF-α stimulation (1 ng/ml, 24 h) significantly increased the adhesion of TK-1 lymphocytes to SVEC monolayers. IL-10 gene transfer significantly reduced TK-1 adhesion in response to TNF-α stimulation at 24 h. IL-10 gene transfer did not modify the basal level of lymphocyte adhesion to the endothelium without TNF-α treatment (n = 7). (* p < 0.05 from TNF-α, # p < 0.05 from control). One-way ANOVA with Fisher's PLSD test.
Sasaki et al. BMC Gastroenterology 2003 3:3 doi:10.1186/1471-230X-3-3