Bacterial cholangitis causing secondary sclerosing cholangitis: A case report
1 Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands
2 Department of Internal Medicine and Gastroenterology, Slotervaart Ziekenhuis, Amsterdam, The Netherlands
BMC Gastroenterology 2002, 2:14 doi:10.1186/1471-230X-2-14Published: 3 June 2002
Although bacterial cholangitis is frequently mentioned as a cause of secondary sclerosing cholangitis, it appears to be extremely rare, with only one documented case ever reported.
A 48-year-old woman presented with an episode of acute biliary pancreatitis that was complicated by pancreatic abcess formation. After 3 months she had an episode of severe pyogenic (E. Coli) cholangitis that recurred over the subsequent 7 months on a further two occasions. Initially, cholangiography suggested the presence of extra-biliary intrahepatic abcesses while repeated investigations demonstrated development of multiple segmental biliary duct strictures. After maintenance antibiotic treatment was started, no episodes of cholangitis occurred over a 14-month period.
Sclerosing cholangitis can rapidly develop after an episode of bacterial cholangitis. Extra-biliary involvement of the hepatic parenchyma with abcess formation may be a risk factor for developing this rare but particularly severe complication.