Table 1 |
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|
Results of the 13 C-UBT in children and adolescents* |
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|
Patients and Methods |
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|
Sample Collection Time [Minutes] |
30 |
60 |
30 |
60 |
30 |
30 |
30 |
30 |
30 |
30 |
60 |
|
Age Limits [Years] |
0.3–5 |
5–8 |
8–11 |
11–14 |
14–18 |
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|
Number of Tests |
251 |
251 |
251 |
251 |
138 |
289 |
383 |
278 |
137 |
1223 |
1232 |
|
Method of Analysis |
LR |
LR |
BM |
BM |
BM |
BM |
BM |
BM |
BM |
BM |
BM |
|
Histology used |
Yes |
Yes |
Yes |
Yes |
No |
No |
No |
No |
No |
No |
No |
|
Threshold Results |
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|
Threshold from Logistic Regression (LR) [‰Δδ] |
5.29 |
6.76 |
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|
SD [‰Δδ] |
0.3 |
0.5 |
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|
R2 LR |
0.91 |
0.85 |
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|
Threshold from Specificity [‰Δδ] |
5.66 |
6.72 |
9.10 |
5.57 |
6.83 |
6.46 |
4.97 |
5.78 |
6.19 |
||
|
SD [‰Δδ] |
4.46 |
1.22 |
0.86 |
1.05 |
1.46 |
0.45 |
0.42 |
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|
Positive plus Negative Predictive Values [‰Δδ] |
5.54 |
6.53 |
12.25 |
7.78 |
8.11 |
7.24 |
5.56 |
7.19 |
7.55 |
||
|
SD [‰Δδ] |
5.10 |
1.66 |
1.00 |
1.19 |
1.76 |
0.56 |
0.53 |
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|
Performance Results |
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|
Sensitivity |
0.95 |
0.93 |
0.91 |
0.94 |
0.94 |
0.91 |
0.98 |
0.98 |
0.97 |
0.96 |
0.96 |
|
Specificity |
0.97 |
0.95 |
0.96 |
0.97 |
0.95 |
0.94 |
0.98 |
0.97 |
0.96 |
0.96 |
0.95 |
|
Positive predictive value |
0.97 |
0.96 |
0.95 |
0.97 |
0.95 |
0.94 |
0.98 |
0.98 |
0.96 |
0.96 |
0.95 |
|
Negative predictive value |
0.95 |
0.92 |
0.89 |
0.92 |
0.98 |
0.97 |
0.99 |
0.99 |
0.98 |
0.99 |
0.99 |
|
AUROC |
0.94 |
0.98 |
0.98 |
0.99 |
0.98 |
0.97 |
0.99 |
0.99 |
0.99 |
0.99 |
0.99 |
|
|
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|
*Mean results from bootstrapping. Empty fields: not applicable. BM: Binormal maximum likelihood modeling. LR: Logistic regression. SD: Standard Deviation. UBT: Urea Breath Test. AUROC: Area under the receiver operator characteristic curve. |
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|
Herold and Becker BMC Gastroenterology 2002 2:12 doi:10.1186/1471-230X-2-12 |
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