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Open Access Highly Accessed Research article

High prevalence of Helicobacter pylori infection in Behcet’s disease

Kamran B Lankarani1*, Mohammad Reza Ravanbod2, Elham Aflaki3, Mohammad Ali Nazarinia3 and Akbar Rajaee3

Author Affiliations

1 Health policy Research Center, Shiraz University of Medical Sciences, P.O. Box 71345–1414, Shiraz, Islamic Republic of Iran

2 Bushehr University of Medical Sciences, Bushehr, Islamic Republic of Iran

3 Rheumatology Research Center, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran

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BMC Gastroenterology 2014, 14:58  doi:10.1186/1471-230X-14-58

Published: 31 March 2014

Abstract

Background

Behcet’s disease (BD) is a multisystem disease of unknown etiology. There are several clues which may indicate an ethiopathogenesis role for Helicobacter pylori infection in this disease.

Methods

In a case control study in an out patient department, 48 patients with BD were compared to age, sex matched controls regarding presence of H. pylori infection by serology and urea breath test (UBT).

Results

Ongoing H. pylori infection was more prevalent among patients with BD using result of UBT with odds ratio of 3.1 (95% CI: 1.34 – 7.26, PV < 0.001).

Conclusion

H. pylori infection may have a role in the pathogenesis of BD.

Keywords:
Helicobacter pylori; Behcet’s disease; Pathogenesis; Urea breath test