Effect of NOD2 variant alleles on treatment in pediatric- and adult-onset CD. CD patients with pediatric-onset (A) or adult-onset (B) of disease with NOD2 variant (grey bars) or NOD2 wild-type alleles (white bars) are compared regarding steroid-dependent or refractory course of disease, need for long-term immunosuppressive therapy with azathioprine (AZA) and methotrexate (MTX) or anti-TNFα antibody. Differences were compared using chi-square or Fishers exact test, respectively. A p-value below ≤0.05 was considered to be significant.
Posovszky et al. BMC Gastroenterology 2013 13:77 doi:10.1186/1471-230X-13-77