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Age-of-onset-dependent influence of NOD2 gene variants on disease behaviour and treatment in Crohn’s disease

Carsten Posovszky1*, Veronika Pfalzer1, Georgia Lahr1, Jan Hendrik Niess2, Jochen Klaus2, Benjamin Mayer4, Klaus-Michael Debatin1 and Georg BT von Boyen3

Author Affiliations

1 Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Eythstr. 24, Ulm, 89075, Germany

2 Internal Medicine, University Medical Center Ulm, Albert Einstein Allee 24, Ulm, 89081, Germany

3 Medical department of the Academic Clinic Sigmaringen, Hohenzollernstr. 40, Sigmaringen, 72488, Germany

4 Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany

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BMC Gastroenterology 2013, 13:77  doi:10.1186/1471-230X-13-77

Published: 2 May 2013

Additional files

Additional file 1: Figure S1:

Effect of age of onset at diagnosis of CD and NOD2 variants on treatment. Th age of onset of CD in 202 patient with NOD2 variant (grey bars) or wild-type (white bars) alleles is compared regarding steroid-dependent or refractory course of disease (A), need for long-term immunosuppressive therapy with azathioprine (AZA) and methotrexate (MTX) (B) or anti-TNFɑ agents (C). Differences were compared using Kruskal-Wallis test. A p-value below ≤0.05 was considered to be significant and indicated with an asterix.

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