Table 3

Randomised participants by medicine group
Variable Mebeverine Methylcellulose Placebo Test
N = 44 N = 46 N = 46
Age (years), mean (SD) 45.44 (7.73) 43.52 (12.22) 44.24 (10.57) F(2,132) = 0.385, p = 0.68
Length of symptoms(years) - mean (SD) 11.20 (8.94) 10.30 (9.05) 10.91 (8.34) KW, ap = 0.783
  Median (IQR) 10.00 (11.00) 8.50 (12.00) 10.00 (11.00)
IBS-SSS total score - mean (SD) 270.02 (77.27) 233.15 (89.19) 224.35 (90.79) F(2,132) = 3.483, p = 0.034*
IBS-QOL score - mean (SD) 59.58 (20.60) 65.70 (18.64) 66.51 (19.49) F(2,132) = 1.65, p = 0.20
HADS score for anxiety- mean (SD) 9.23 (4.02) 9.57 (4.19) 9.37 (3.30) F(2,132) = 0.84, p = 0.92
HADS score for depression - mean (SD) 5.76 (3.75) 4.22 (4) 4.93 (3.25) KW, ap = 0.109
  Median (IQR) 6.00 (6.00) 3.00 (4.00) 4.00 (6.00)
Deprivation score, mean (SD) 12.19 (8.57) 11.38 (8.87) 10.12 (7.52) KW, ap = 0.499
  Median (IQR) 10.06 (9.71) 8.00 (9.56) 8.25 (7.26)
Gender - n (%)
  Male 12 (40.0) 9 (30.0) 9 (30.0) X2(2) = 1.18, p = 0.57
Female 31 (29.5) 37 (35.2) 37 (35.2)
  Type of IBS - n (%)
  Constipation 5 (38.5) 3 (23.1) 5 (38.5) X2(4) = 0.893, p = 0.932
  Diarrhoea 13 (31.7) 15 (36.6) 13 (31.7)
  Mixed 25 (30.9) 28 (34.6) 28 (34.6)
Severity IBSon IBS SSS n (%) X2(4) = 11.48, p = 0.021*
  Mild 3 (10.0) 11 (36.7) 16 (53.3)
  Moderate 26 (35.1) 27 (36.5) 21 (28.4)
  Severe 14 (45.2) 8 (25.8) 9 (29.0)
Education - n (%)
  No formal 4 (50) 3 (37.5) 1 (12.5) X2(10) = 5.67, p = 0.85
  GSCE/O 12 (34.3) 9 (25.7) 14 (40)
  A level 10 (29.4) 12 (35.3) 12 (35.3)
  Degree 8 (25.8) 11 (35.5) 12 (38.7)
  Postgraduate 6 (40.0) 5 (33.3) 4 (26.7)
  Other 3 (25.0) 6 (50.0) 3 (25)

Everitt et al.

Everitt et al. BMC Gastroenterology 2013 13:68   doi:10.1186/1471-230X-13-68

Open Data