a-d. The endocytoscopic counts of nuclei are significantly improved after POEM (a). Also, the mean Ki-67-positive ratios before and after the procedure are 26.0 (median 25.4, 10.3-33.2) and 20.7 (median 20.0, 13.1-29.9), respectively (p = 0.07) (b, c). The mean p53-positive ratios before and after the procedure are 2.35 (median 2.61, 0.32-4.23) and 0.97 (median 1.49, 0.32-1.56). There was a significant positive correlation between the esophageal epithelial nuclei numbers assessed by endocytoscopy and the Ki-67-positive ratios (correlation coefficient, 0.695, p < 0.05) (Figure 4d).
Minami et al. BMC Gastroenterology 2013 13:22 doi:10.1186/1471-230X-13-22