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Open Access Research article

MYC, FBXW7 and TP53 copy number variation and expression in Gastric Cancer

Danielle Queiroz Calcagno*, Vanessa Morais Freitas, Mariana Ferreira Leal, Carolina Rosal Teixeira de Souza, Samia Demachki, Raquel Montenegro, Paulo Pimentel Assumpção, André Salim Khayat, Marília de Arruda Cardoso Smith, Andrea Kely Campos Ribeiro dos Santos and Rommel Rodriguez Burbano

BMC Gastroenterology 2013, 13:141  doi:10.1186/1471-230X-13-141

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The Role of Fbxw7 in the Inversed Expression Pattern between CD44v and c-Myc

Go Yoshida   (2014-08-04 12:03)  School of Medicine, Keio University email

CD44 variant isoform (CD44v) is widely recognized to be a functional cancer stem cell marker to reduce reactive oxygen species. The inversed pattern was firstly identified in the normal gastric mucosa as well as tumor xenograft model. CD44v8-10(+) cells do not easily activate canonical Wnt signaling pathway as CD44v8-10(-) cells, which is why GRHL2-ESRP1-CD44v-xCT-GSH (glutathione) axis is regarded to be critical to repress the up-regulation of proto-oncogenic molecules such as c-Myc. Tumor tissue at the invasive area is considered to be composed of heterogeneous cellular population; dormant cancer stem-like cells with CD44v8-10 high/ Fbw7 high/ c-Myc low and proliferative cancer stem-like cells with CD44v8-10 high/ Fbw7 low/ c-Myc high.

 Ref

Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation (Biochem Biophys Res Commun. 2014 Jan10;443(2):622-7.).

Competing interests

No Competing Interests Exist.

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