Dissemination of C. rodentium from the intestine causes liver injury in GC-C−/− mice at day 10 following infection. A: In colonized mice, GC-C−/− livers had significantly more C. rodentium CFU/g as compared to GC-C+/+ livers. (*P ≤ 0.003). B: Gross areas of necrosis were apparent in the livers of some GC-C−/− mice at necropsy while none were seen in GC-C+/+ livers. C: Representative photomicrographs illustrate the presence of lymphocyte aggregates (black arrows) and areas of hemorrhage visible only in GC-C−/− mice (original magnification 200x).
Mann et al. BMC Gastroenterology 2013 13:135 doi:10.1186/1471-230X-13-135