Colonocyte hyperplasia is increased in response to infection to a similar extent in both GC-C+/+ and GC-C−/− mice. A: Analysis of distal colon of naïve and day 10 p.i. mice revealed that there was no substantial difference in histopathology or epithelial cell hyperplasia in GC-C+/+ and GC-C−/− mice. Scale bars = 100 μm, original magnification 400X. B: Quantitative analysis revealed a significant difference in crypt depth in the distal colon of uninfected GC-C−/− mice compared to GC-C+/+ mice (n = 4 per group with a minimum of 30 crypts counted per mouse). In response to infection, the distal colons of both GC-C+/+ mice and GC-C−/− mice show a significant increase in crypt depth (n = 12 per group with a minimum of 16 crypts per mouse). Data is presented as the mean with SE. (*P ≤ 0.0001, Student t test).
Mann et al. BMC Gastroenterology 2013 13:135 doi:10.1186/1471-230X-13-135