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Open Access Research article

GERD assessment including pH metry predicts a high response rate to PPI standard therapy

Arne Kandulski1, Ulrich Peitz12, Klaus Mönkemüller13, Helmut Neumann14, Jochen Weigt1 and Peter Malfertheiner1*

Author Affiliations

1 Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany

2 Department of Internal Medicine II and Gastroenterology, Loerstraße 23, 48143, Münster, Germany

3 Department of Internal Medicine, Gastroenterology, Marienhospital Bottrop, Josef-Albers-Str. 70, 46236, Bottrop, Germany

4 Department of Medicine 1, University of Erlangen-Nuremberg, Ulmenweg 18, 91054, Erlangen, Germany

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BMC Gastroenterology 2013, 13:12  doi:10.1186/1471-230X-13-12

Published: 16 January 2013

Abstract

Background

Inadequate response to proton pump inhibitor (PPI) therapy in patients with gastroesophageal reflux disease (GERD) is reported in up to 40%. Patients with non erosive reflux disease (NERD) have lower response rates compared to patients with erosive reflux disease (ERD); pH metry contributes to GERD diagnosis and is critical for proper diagnosis of NERD.

Aim of the study was to assess the need for doubling esomeprazole standard dose (40 mg) for 4 weeks in PPI naive patients with typical reflux symptoms and diagnosis of GERD based on endoscopy and 48 hours, wireless pH metry.

Methods

All patients underwent upper GI endoscopy. Symptoms were recorded with a structured questionnaire (RDQ) and acid exposure was determined by 48 hours, wireless pH monitoring (BRAVO). In case of abnormal acid exposure, patients received a short term treatment with esomeprazole 40 mg q.d. for 4 weeks. If symptoms persisted, patients underwent a second pH metry on PPI and the dose was increased to 40 mg b.i.d.

Results

31 consecutive patients with typical reflux symptoms underwent 48 hours pH monitoring. 22 patients (71%) had abnormal acid exposure, 9 patients had normal pH metry (29%). Of the 9 patients with normal pH metry, 2 were found with erosive esophagitis and 7 without endoscopic abnormalities.

24 patients with documented GERD received esomeprazole treatment. 21 patients achieved complete symptom resolution with 40 mg q.d. after 4 weeks (88%). Only 2 patients required doubling the dose of esomeprazole for complete symptom resolution, 1 patient remained with symptoms.

Conclusions

Patients with typical reflux symptoms and abnormal acid exposure have a high response rate to standard dose esomeprazole regardless of whether they have ERD or NERD.

Keywords:
GERD; NERD; PPI; Esomeprazole; Treatment; ph metry; Diagnosis; Therapy