Table 3

Test characteristics of fecal calprotectin to predict a clinically significant gastrointestinal finding

Clinically significant finding

AUC (95%CI)

Cut-off (μg/g)

Sens

(%)

Spec

(%)

LR+

LR-

NPV (%)

PPV (%)

Accuracy (%)

Overall

0.877 (0.85 - 0.90)

50

73

93

10.8

0.29

88

84

85

Upper gastrointestinal tract

0.730 (0.66 - 0.79)

48

59

82

3.2

0.50

75

68

71

Lower gastrointestinal tract

0.912 (0.88 - 0.94)

50

84

92

10.6

0.17

82

93

89

Area under the receiver operating characteristics curve (AUC) with corresponding sensitivity (Sens), specificity (Spec), positive and negative likelihood ratio (LR+, LR-), and negative and positive predictive values (NPV, PPV) for fecal calprotectin to identify a clinically significant finding in the gastrointestinal tract. Overall accuracy was calculated using the following formula: (true positive test results + true negative test results)/total population.

Manz et al. BMC Gastroenterology 2012 12:5   doi:10.1186/1471-230X-12-5