sIL-2R levels of are associated with circulating monocyte subpopulations. (A) CD25 expression was studied by FACS on circulating monocyte subsets. A representative histogram displays that CD14+CD16+ monocytes express higher levels of CD25 than the classical CD14++ monocytes. (B) FACS plots from two representative patients display an increase of CD14+CD16+ monocytes (right gate) among freshly isolated PBMC. The left plot is derived from a patient with Child A cirrhosis (corresponding sIL-2R 520 kU/L) and the right plot from patient with Child C cirrhosis (sIL-2R 1203 kU/L). (C) Serum levels of sIL-2R correlate with numbers of total circulating monocytes (left plot), classical CD14++ monocytes (middle plot) and CD14+CD16+ monocytes (right plot, Spearman rank correlation test).
Seidler et al. BMC Gastroenterology 2012 12:38 doi:10.1186/1471-230X-12-38