Open Access Research article

Do gastrointestinal and respiratory signs and symptoms correlate with the severity of gastroesophageal reflux?

Hakan Uzun1*, Demet Alagoz1, Mesut Okur1, Bunyamin Dikici1, Kenan Kocabay1, Dursun Ali Senses1, Aybars Ozkan2 and Murat Kaya2

Author Affiliations

1 Department of Pediatrics, Duzce University School of Medicine, 81620 Konuralp, Duzce, Turkey

2 Department of Pediatric Surgery, Duzce University School of Medicine, Duzce, Turkey

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BMC Gastroenterology 2012, 12:22  doi:10.1186/1471-230X-12-22

Published: 21 March 2012



Gastroesophageal reflux (GER) is a disorder that is common by seen in childhood and may lead to severe complications. In this study, we ascertained the incidence of GER among the children who had typical and atypical complaints of GER and whether there was a difference between two groups comparing the findings of 24-hour pH-meter.


39 out of 70 patients with typical and atypical GER symptoms were diagnosed as GER by 24-hour pH-meter monitoring. The patients were divided into three groups, those having gastrointestinal complaints, those having respiratory complaints and those having both gastrointestinal and respiratory symptoms.


Evaluated the GER prevalence in these groups, it was found to be 60% in the gastrointestinal group, 48.6% in the respiratory group and 75% in the mixed group. When pH-meter measurements of GER positive patients were compared within the clinical groups, the fraction of time that pH was lower than 4 was found to be significantly higher in the mixed group (p = 0.004).


The coexistence of gastrointestinal and respiratory symptoms in the patients with GER may be related to the severe reflux.