Table 4

Odds ratios of esophageal cancer in relation to use of anti-diabetic drugs
Use of anti-diabetic drugs Case Control Odds ratio (95% CI)
Number (%) Model 1 Model 2
Insulins
never use 7(12.3) 69(31.1) 1.00 1.00
ever use 50(87.7) 153(68.9) 3.27(1.40-7.60) 2.58(1.08-6.15)
Metformin
never use 5(8.77) 43(19.4) 1.00 1.00
ever use 52(91.2) 179(80.6) 2.34(0.87-6.24) 2.84(0.99-8.18)
Sulfonylureas
never use 4(7.02) 38(17.1) 1.00 1.00
ever use 53(92.9) 184(82.9) 2.75(0.94-8.10) 3.80(1.16-12.5)
Thiazolidinediones
never use 49(86.0) 180(81.1) 1.00 1.00
ever use 8(14.0) 42(18.9) 0.65(0.28-1.49) 1.11(0.46-2.65)
Alpha-glucosidase inhibitors
never use 48(84.2) 188(84.7) 1.00 1.00
ever use 9(15.8) 34(15.3) 1.00(0.44-2.24)

Model 1 was adjusted for age and sex.

Model 2 was additionally adjusted for sex, age, alcoholism, periodontal disease, esophagus ulcer, esophagus reflux, other NSAIDs and COX-2 inhibitors.

Cheng et al.

Cheng et al. BMC Gastroenterology 2012 12:177   doi:10.1186/1471-230X-12-177

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