Table 3

Incidence of gallbladder surgery among tegaserod initiators and comparators (as-matched analysis)
Variable Events Person years I.R.1 95% Confidence interval Hazard ratio2 95% Confidence interval Hazard ratio3 95% Confidence interval
Low High Low High Low High
Exposure
 Tegaserod Initiators 36 1,115 0.03 0.02 0.04 0.98 0.62 1.55 0.99 0.62 1.58
 Comparators 37 1,125 0.03 0.02 0.05 1.00 1.00
Gender
 Female 67 1,999 0.03 0.03 0.04 1.00 1.00
 Male 6 242 0.02 0.01 0.05 0.76 0.33 1.75 0.50 0.20 1.24
Age
 0 – 29 9 299 0.03 0.01 0.06 0.77 0.56 1.21 0.77 0.56 1.22
 30 – 49 45 1144 0.04 0.03 0.05 1.00 1.00
 50 + 19 797 0.02 0.01 0.04 0.61 0.55 0.81 0.61 0.52 0.83
Gallbladder Surgery Risk Factors
 Other Diseases of Appendix 1 2 0.49 0.01 2.71 13.60 1.77 401.41
 Gallbladder or Bile Duct Surgeries 3 30 0.10 0.02 0.29 0.07 0.02 0.31
 Acute Cholecystitis (575.0) 4 8 0.47 0.13 1.21 5.34 1.42 20.06
 Cholelithiasis (574) 14 44 0.32 0.18 0.54 8.59 4.09 18.01
 Constipation (564.0) 17 814 0.02 0.01 0.03 0.58 0.33 1.00
 Abdominal Ultrasound 33 283 0.12 0.08 0.02 2.84 1.62 4.98
 Radiographic Visualization, Gallbladder 13 51 0.25 0.13 0.43 3.31 1.63 6.71

1 Incidence rate (IR) per person year.

2 Adjusted for age, gender, region, and calendar year and quarter of cohort entry.

3 Adjusted for age, gender, region, and calendar year and quarter of cohort entry, number of abdominal pain physician visits, appendicitis, gallbladder surgery, cholecystitis, cholelithiasis, constipation, disorders of stomach and duodenum, liver surgery, peptic ulcer disease, sucralfate, abdominal ultrasound, and radiographic visualization of the gallbladder.

Seeger et al.

Seeger et al. BMC Gastroenterology 2012 12:171   doi:10.1186/1471-230X-12-171

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