Table 2

Incidence of abdominal or pelvic surgeries among tegaserod initiators and comparators (as-matched analysis)
Variable Events Person years I.R.1 95% C.I. Hazard ratio2 95% C.I. Hazard ratio3 95% C.I.
Low High Low High Low High
Exposure
 Tegaserod Initiators 94 1,101 0.09 0.07 0.10 0.70 0.54 0.91 0.71 0.55 0.93
 Comparators 134 1,100 0.12 0.10 0.14 1.00 1.00
Gender
 Female 207 1,963 0.11 0.09 0.12 1.00 1.00
 Male 21 237 0.09 0.05 0.14 0.83 0.53 1.31 0.74 0.47 1.18
Age
 0 – 29 25 295 0.08 0.06 0.12 0.65 0.45 0.96 0.63 0.41 0.94
 30 – 49 146 1118 0.13 0.11 0.15 1.00 1.00
 50 + 57 788 0.07 0.06 0.09 0.55 0.26 0.94 0.65 0.30 1.02
Abdominal Surgery Risk Factors
 Cholelithiasis 19 43 0.45 0.27 0.69 5.06 2.85 8.96
 Inguinal Hernia 3 7 0.43 0.09 1.27 3.82 1.17 12.49
 Diagnostic Procedures, Abdomen/Pelvis 3 5 0.61 0.13 1.79 4.34 1.32 14.22
 Radiologic Small Bowel Exam 21 59 0.35 0.22 0.54 2.35 1.43 3.86
 Urinary Tract Diagnostic Procedures 15 71 0.21 0.12 0.35 2.11 1.14 3.90
 Gallbladder Radiography 19 50 0.38 0.23 0.60 2.82 1.69 4.69

1 Incidence rate (IR), events per person year.

2 Adjusted for age, gender, region, calendar year and quarter of cohort entry.

3 Adjusted for. age, gender, region, antidepressants, appendicitis, gallbladder surgeries, cholelithiasis, colonoscopy, irritable bowel syndrome, gastritis/duodenitis, hepatitis, disorders of liver, inguinal hernia, male genital surgery, MRI abdomen, diagnostic procedures, abdomen/pelvis, small bowel radiology, rectum/anus diagnostic procedures, urinary tract diagnostic procedures, urinary tract surgeries, gallbladder radiography, abdominal radiology, calendar year and quarter of cohort entry.

Seeger et al.

Seeger et al. BMC Gastroenterology 2012 12:171   doi:10.1186/1471-230X-12-171

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