Table 6

Allele frequencies of GNB1 single nucleotide polymorphisms stratified by gender in HCV-1- and HCV-2-infected patients receiving PEG-IFNα-RBV therapy with and without RVR in a Chinese population in Taiwan
HCV-1 HCV-2
SNP ID RVR (+) N (%) RVR (−) N (%) Pvalue OR (95% CI) SNP ID RVR (+) N (%) RVR (−) N (%) Pvalue OR (95% CI)
Males
rs10907185 rs10907185
A allele 36 (32.7) 40 (27.0) 1.31 (0.77, 2.25) A allele 43 (28.7) 6 (23.1) 1.34 (0.50, 3.56)
G allele 74 (67.3) 108 (73.0) 0.3206 1 G allele 107 (71.3) 20 (76.9) 0.5572 1
rs6603797 rs6603797
C allele 99 (90.0) 124 (83.8) 1.74 (0.81, 3.73) C allele 135 (90.0) 25 (96.2) 0.36 (0.05, 2.85)
T allele 11 (10.0) 24 (16.2) 0.1493 1 T allele 15 (10.0) 1 (3.8) 0.3136 1
rs4648727 rs4648727a
A allele 39 (35.5) 49 (33.1) 1.11 (0.66, 1.87) A allele 57 (38.0) 5 (20.8) 2.33 (0.82, 6.58)
C allele 71 (64.5) 99 (66.9) 0.6942 1 C allele 93 (62.0) 19 (79.2) 0.1030 1
rs12126768 rs12126768
G allele 23 (20.9) 40 (27.0) 0.71 (0.40, 1.28) G allele 35 (23.3) 4 (15.4) 1.67 (0.54, 5.18)
T allele 87 (79.1) 108 (73.0) 0.2580 1 T allele 115 (76.7) 22 (84.6) 0.3676 1
Females
rs10907185 rs10907185
A allele 29 (27.4) 40 (24.1) 1.19 (0.68, 2.07) A allele 45 (27.1) 10 (20.8) 1.41 (0.65, 3.07)
G allele 77 (72.6) 126 (75.9) 0.5465 1 G allele 121 (72.9) 38 (79.2) 0.3809 1
rs6603797 rs6603797
C allele 94 (88.7) 146 (88.0) 1.07 (0.50, 2.30) C allele 150 (90.4) 42 (87.5) 1.34 (0.49, 3.64)
T allele 12 (11.3) 20 (12.0) 0.8559 1 T allele 16 (9.6) 6 (12.5) 0.5653 1
rs4648727a rs4648727
A allele 31 (29.2) 58 (35.4) 0.76 (0.45, 1.28) A allele 54 (32.5) 12 (25.0) 1.45 (0.70, 3.00)
C allele 75 (70.8) 106 (64.6) 0.2961 1 C allele 112 (67.5) 36 (75.0) 0.3198 1
rs12126768a rs12126768
G allele 22 (20.8) 46 (28.0) 0.67 (0.38, 1.20) G allele 40 (24.1) 12 (25.0) 0.95 (0.45, 2.00)
T allele 84 (79.2) 118 (72.0) 0.1776 1 T allele 126 (75.9) 36 (75.0) 0.8977 1

a: Contains 1 missing data point in the RVR (−) group.

Abbreviations: SNP, single nucleotide polymorphism; RVR, rapid virological response; OR, odds ratio; CI, confidence interval.

Allele frequencies were determined by the χ2 test using 2 × 2 tables. Odds ratios and 95% CI per genotype were estimated by unconditional logistic regression. P values less than 0.05 were considered statistically significant.

Lim et al.

Lim et al. BMC Gastroenterology 2012 12:167   doi:10.1186/1471-230X-12-167

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